207_Combined course Presentations
LAG3: CD4 homologue, binding MHC II
Function
Expression
Confers a Treg function on CD4 naïve T cells
•
On exhausted T cells
• • • •
On TIL
On T regs
LAG3 negatively regulates • T-cell activation • Proliferation • Homeostatic expansion
On NK
Adapted from Nature Reviews Immunology 15; 2015: 45-56
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