207_Combined course Presentations

FFCD 9901 trial

Surgery alone versus chemoradiotherapy followed by surgery for localized esophageal cancer :

Early stages : Stage I&II (T1-T1, N0-1, T3N0) cN1: #25%; cT3: #18% 5FU-CDDP/ RT: 45 Gy

RT-CT Surg alone

Nbre pts

98

97

Post-op Mortality (%)

11.1

3.4

0.049

5-yr survival (%)

41.1

33.8

NS

Local recurrences (%)

22.1

28.9

0.02

R0 resection (%)

93.8

92.1

Per-op. RT-CT is not useful for early stages

Mariette, J Clin Oncol, 32:2416-2422, 2014