207_Combined course Presentations

Pre-operative CT or RT-CT?

 Swedish randomized trial  3 cycles of Cisplatin/5FU  ± Radiotherapy: 40 Gy

Overall survival

CT RT-CT

N pts

91

90

90-day mortality (%) 3 8 0.12 Post-op complications (%) 35 38 0.28 pCR (%) 9 28 0.002 R0 resection (%) 74 87 0.042 pN1 62 35 0.001

On Going trials: - Irish neo-AGIS: MAGIC vs CROSS - Japan

Klevebro, Ann Oncol, 2016, 27: 660-667