207_Combined course Presentations

Predictive factors of chemo- radiosensitivity

• Apoptosis: p53, p21, Survivin, bcl2

• Tumour proliferation: NF- k B, COX-2, cyclins

• EGFR, HER-2

• DNA repair: ERCC1

•Tumour hypoxia

• Thymydylate synthase (5FU)

• Metallothionein, GST- P , P-glycoprotein (cisplatin)

• Gene expression arrays

• SNPs for AKT, PTEN, …