207_Combined course Presentations

EGFR as an example

- IR +2Gy

-

+

R

R

EGF

P-EGFR

P-EGFR

RAS RAF

K

K

SOS

PI3-K

pY

pY

GRB2

pY

MEK

STAT

PTEN

AKT

MAPK

Gene transcription Cell cycle progression hemo- and radiotherapy resistance myc cyclin D1 P P

proliferation/ maturation

Cyclin D1

DNA

JunFos

metastasi

Myc

Survival / anti-apoptosis

angiogenesis