207_Combined course Presentations

5-FU and RT

• Thymidin 5-tri-P analogue

• Inhibition of TS

• Deplete Thymidine 5 mono-P and Thymidine 5 tri-P

• lnhibition of DNA synthesis

• Interference with DNA repair.

• S-phase specific (RT-resistent)

• Inhibit S-phase entry

Longley DB 2003