207_Combined course Presentations

EORTC/DAHANCA 29 randomized phase III

Role of Nimorazole in chemo-radiation of HPV neg HNSCC

LARYNX, PHARYNX*

* Except NPC

HPVneg (p16); Stage 3-4 (T2-4,N0-3)

Stratify:

Accl RT (6 fx/wk) +cisPl

Stage Site Inst. Hypox. Gene profile (retro-spective)

640 patients – (>200 with positive hypoxic gene profile).

Pivotal trial to establish the true indication of Nimorazole in Chemoradiotherapy of advanced HNSCC and the value of the hypoxic gene profile

RANDOMIZE

+ Nimorazole (1.2 g/m2) Accl RT (6 fx/wk) +cisPl