207_Combined course Presentations

Clinical features

 Sites of presentation • Brain • Leptomeninges • Eye (PIOL) • Spinal cord  Mean age = 60  Gender : M/F = 1:1



23% ocular involvement



17% positive CSF cytology



Symptoms •

51% behavioral/personality

28% hemiparesis

•

• 13% seizure  Chemo-radiotherapy is the most commonly used strategy

 Efficacy of chemo: limited by special functional and micro-environmental characteristics of the CNS (BBB)  Consolidation after chemotherapy represents the best role for radiotherapy (whole brain RT due to infiltrative nature of PCNSL)