207_Combined course Presentations

PCNSL [≤ 65 ys. + PS 0-3] or [65-70 ys. + PS ≤2]

®

MTX 3.5 g/m 2 d.1 araC 2 g/m 2 x 2/d, d. 2-3 every 3 weeks

Rituximab 375 mg/m 2 d-5 & 0 MTX 3.5 g/m 2 d.1 araC 2 g/m 2 x 2/d, d. 2-3 every 3 weeks

Rituximab 375 mg/m 2 d-5 & 0 MTX 3.5 g/m 2 d.1

araC 2 g/m 2 x 2/d, d. 2-3 Thiotepa 30 mg/m 2 d.4 every 3 weeks

Response assessment

CR – PR - SD

PD – tox  SC harvest

®

WBRT 40 Gy ± boost 9 Gy

BCNU 400 mg/m 2 d.1 Thiotepa 5 mg/Kg x 2/d; d.2-3 + APBSCT

WBRT 36 Gy ± boost 9 Gy