6th ICHNO Abstract Book

6th ICHNO 6 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 16 – 18 March 2017 Barcelona, Spain __________________________________________________________________________________________ hypofractionated radiotherapy 55 Gy in 20 fractions over 4 weeks for glottis carcinoma. Material and Methods page 29

were enrolled in our study. The patients were treated with IMRT or 3DCRT plan for External beam radiation therapy to standard dose of 60Gy in 30 fractions with 200cGy dose 5 times a week over 6 weeks. Of the 50 cases, 26 received adjuvant chemotherapy. The patients were given EORTC Qol 30 and QoL HN 35 at start of treatment, at completion of radiation therapy and subsequently at 1 month and 3 months of follow up. The skin reactions were assessed using EORTC and CTCAE 3.0 toxicity grading scales. The scores were analyzed and subsequently the toxicity grades were looked in to and compared and outcome was assessed. Results Out of the 100 patients, 76 developed skin toxicity as per the scales; of which 56 developed grade I toxicity and 20 developed grade II toxicities. The questionnaires were assessed with suitable statistical analysis and no statistical significant was found in the 3DCRT or IMRT arms. However, with increasing grade of tumor, the Qol showed a significant difference in the physical and functional symptoms. The skin toxicity too showed a statistically significant outcome with varying grades of the tumor assessed. The evaluation of toxicities and subsequent management reveleaed better outcomes in the QoL at the end of 3 months wherein the acute form of the toxicities subsided. None of them developed grade 3 or 4 skin toxicities Conclusion The morbidity associated with skin reactions related to radiation therapy in head and neck malignancies were high in 2D era and now with advent of conformal therapy there is a reduction in the cases of the same. However, the incidence can still be reduced further with proper review of patients during treatment and assessment of quality of life. The acute reactions can be prevented to develop in to chronic complications which increase further the morbidity of such patients. Appropriate management of such cases at the right time helps in improving the quality and make the treatment an even better option. PO-058 Nasopharingeal carcinoma treated with intensity modulated radiotherapy in an non–endemic area. A. Lozano 1 , A. Navarro 1 , H. Letelier 1 , S. Vazquez 2 , V. Navarro 3 , J. Nogues 4 , R. Mesia 5 1 Institut Català d'Oncologia, Radiation Oncology Department, L'Hospitalet de Llobregat, Spain 2 Institut Català d'Oncologia, Medical Oncoly Department, L'Hospitalet de Llobregat, Spain 3 Institut Català d'Oncologia, Clinical Investigation Unit, L'Hospitalet de Llobregat, Spain 4 Hospital Unversitari de Bellvitge, Otorhinolaryngology department, L´Hospitalet, Spain 5 Institut Català d'Oncologia, Medical Oncology Department, L'Hospitalet de Llobregat, Spain Purpose or Objective NFC is frequent in some areas but not in Europe. There is a few information in non-endemic population. The aim of this study is to describe and analyze the results in treating all- stages NPC with IMRT-simultaneous integrated boost (SIB), in a non-endemic area. Material and Methods A retrospective review of 62 consecutive patients with NPC treated with curative intention with IMRT- SIB between 2007-14 in a single institution. RT scheme: 33 daily fractions,1.64 Gy to intermediate- risk volume, 2.12 Gy to high-risk volume. Total dose 54.12 Gy and 69.96 Gy respectively. Overall survival (OS), loco-regional relapse- free survival (LRRFS), and progression free survival

Patients aged over 70 years and treated for glottic cancers with definitive radiotherapy, between 2007 and 2014, were retrospectively identified. Characteristics reflective of fitness (smoking status, performance status and ACE 27 score) as well as tolerance (compliance with radiotherapy, need for acute hospitalisation during treatment, need for enteral feeding, 30-day mortality) were collected. The probabilities of local control, disease free and overall survival were calculated using Kaplan-Meier statistics. Univariate Cox Regression investigated factors potentially important in outcome. Results 53 patients were identified. Median age was 76 years (71 – 91). Median follow up was 40.1 months (range 1.1 -103.3 months). 24 (45%), 26 (49%) and 3 (6%) had T1, T2 and T3 disease respectively. Two and three year local control, DFS and OS rates were 85%, 80% and 76% and 83%, 77% and 71% respectively. On univariate analysis, there was no significant difference in outcomes for T1 and T2 disease: 2-year local control and DFS were 85%, 84% for T1 and 89% and 89% for T2 respectively. No other factors (e.g. age, gender, T-stage or histological grade) significantly influenced local control, DFS or OS, with the exception of ACE 27 Score (0-1 versus 2-3), which significantly influenced overall survival (ACE 27 score 2/3 vs 0/1: hazard ratio: 2.65, 95% confidence interval 1.22-5.77, p=0.014). All patients were able to complete their course of treatment with 6/53 patients experiencing a treatment delay of >3 days (median 28 days (26-34)). A total of 11/53 (21%) patients required hospital admission during treatment; 9 (17%) for enteral tube feeding and 2(4%) for symptom management. 30 day mortality was 0%. All 8 patients with a local recurrence were offered salvage options. Of these 5 patients underwent salvage surgery with 2 recurrences (1 local, 1 distal)and 3 patients disease free on follow up; 3 refused salvage surgery. Conclusion Patients aged over 70 years tolerate definitive hypofractionated radiotherapy with high rates of local control. Comorbidity scoring with the ACE 27 scale is an independent prognostic factor for overall survival. PO-057 Radiation induced skin reaction in head neck malignancies and assessment of quality of life V. Pareek 1 , M. Chandra 2 , R. Bhalavat 2 1 Jupiter Hospital- Thane, Radiation Oncology, Mumbai, India 2 Jupiter Hospital, Radiation Oncology, Thane, India Purpose or Objective To evaluate the skin reactions in patients receiving head and neck radiation and assessing the outcomes of the same in respect to the modality of the treatment. Head and Neck malignancies for the bulk of cancer cases in India and Radiation therapy forms a part of management of the same. With Radiation fractionations delivered either with IMRT or 3DCRT, there is a risk of development of skin reactions during the treatment period and can lead to varying degree of complications i.e. infection, ulcerations or even necrosis. The assessment of skin reactions needs to be looked in to as it can be easily avoided with proper prophylaxis and the progression can be managed at an earlier stage. We present our institutional experience in the treatment of the head and neck cancer case treatment. Material and Methods In a prospective, non-randomized study of 100 histo- pathologically proven head and neck cancer cases of various subsites, planned for adjuvant radiation therapy,