6th ICHNO Abstract Book

page 36 6 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 16 – 18 March 2017 Barcelona, Spain __________________________________________________________________________________________ Conclusion 6th ICHNO

Material and Methods From February 2009 to December 2015 patients with nonmetastatic stage III-IV were evaluated in a multidisciplinary board and assigned to CRT or IC followed by CRT. IC consisted of TPF (cisplatin, docetaxel, and fluorouracil), PF (cisplatin, fluorouracil), TCF (carboplatin, Docetaxel, and fluorouracil) and TP (cisplatin, docetaxel). The chemotherapy administered concurrently to most patients was cisplatin, given days 1, 22 and 43. Adverse events were assessed according to the common toxicity criteria of adverse events (CTCAE v. 4.0) and survivals were estimated using Kaplan-Meier method. Results The median follow-up was 29 months. A total of 138 patients were treated, 78 (56,5%) with CRT and 60 (43,5%) with IC followed by CRT. At 3 years the overall survival for CRT versus IC followed by CRT was 50, 4% vs 34, 3%, respectively (p = 0,006). The Local control at 3 years was also higher for CRT compared to IC followed by CRT, 61% vs 42,4% (p= 0,02). The most common grade 4 toxicity during IC was leukopenia and during QRT the hematologic and non-hematologic toxicities were similar in both treatment modalities. Conclusion Results suggest that CRT was associated with higher overall survival and local control and that IC did not improve the distant control. PO-075 Treatment of nasopharyngeal cancer: a Serbian institututinal experience T. Ursulovic 1 , N. Babovic 1 1 Institute for Oncology and Radiology of Serbia, Medical Oncology, Belgrade, Serbia Purpose or Objective Since 2005.-2012. we have treated patients with advanced nasopharyngeal cancer (NPC) with neoadjuvant chemotherapy, concomitant chemoradiotherapy (CHRT) adjuvant chemotherapy. We herein report the results of our experience. Material and Methods There were 73 patients with previously untreated stage III (41,1%), IVa (19,3%) and IVb (38,6%) NPC. The median age was 52 years. Two cycles of neoadjuvant chemotherapy consisting of Epirubicin and Cisplatin, 90mg/m2 of each, were administered followed by CHRT with two same cycles but at the dose of 60mg/m2 of each drug and once- daily RT 2Gy/ day (median RTdose was 70GY). Finally, patients received adjuvant chemotherapy at the same dose as neoadjuvant approach. Results Response to neoadjuvant therapy was 72,6%: complite response (CR)1,4% and partial responce (PR)71.2%. After that, 15,5% patiemts had neck dissection. 69 patients completed CHRT. Response to CHRT was 92%: CR 37,7% and PR 53,6%, 57 patients received adjuvant treatment.Therewere 98,2% response, CR 84,2% and PR 14%. The progression' free' survival (PFS) at 3 and 5 years was 76,5% and 65,3%, respectivaly. Overall survival (OS) at3 and 5 years was 79% and 67,1%, respectivaly. Median od PFS and OS not achieved. Conclusion Treatment og locoregioally advanced NPC with induction chemotherapy, CHRT andadjuvant chemotherapy resulted in very good OS. These results are encouraging. A phase III study to definitively test this treatment strategy is warranted. PO-076 Predictive and prognostic value of pretreatment fdg-pet suv parameters in head-and-neck

Induction chemotherapy followed with concurrent chemo radiotherapy and adjuvant chemotherapy is feasible treatment, but with high rate of severe acute toxicity grade 3/4. PO-073 Viable tumour in salvage neck dissections: relation with initial treatment, lymph node size and HPV K. Van den Bovenkamp 1 , B. Dorgelo 2 , M.G. Noordhuis 1 , B.F.A.M. Van der Laan 1 , B. Van der Vegt 3 , H.P. Bijl 4 , J.L. Roodenburg 5 , B.A.C. Van Dijk 6 , G.B. Halmos 1 , E.M.D. Schuuring 3 , J.A. Langendijk 4 , S.F. Oosting 7 , B.E.C. Plaat 1 1 UMCG University Medical Center Groningen, ENT Head and Neck Surgery, Groningen, The Netherlands 2 UMCG University Medical Center Groningen, Radiology, Groningen, The Netherlands 3 UMCG University Medical Center Groningen, Pathology, Groningen, The Netherlands 4 UMCG University Medical Center Groningen, Radiotherapy, Groningen, The Netherlands 5 UMCG University Medical Center Groningen, Oral and Maxillofacial Surgery, Groningen, The Netherlands 6 UMCG University Medical Center Groningen, Epidemiology, Groningen, The Netherlands 7 UMCG University Medical Center Groningen, Medical Oncology, Groningen, The Netherlands Purpose or Objective The objective of this study was to identify predictive factors for the presence of viable tumor and outcome in therapeutic salvage neck dissections in head and neck Retrospective analysis of 87 salvage neck dissections after radiotherapy alone (n=30), radiotherapy in combination with carboplatin/5-FU (n=43) or with cetuximab (n= 14). Results Viable tumor was detected in 47% of all neck dissections and was associated with poor survival. Univariate analysis revealed initial treatment with radiotherapy alone (OR 7.12, p < .001), clinical suspicion of recurrence during follow-up (OR 7.10, p = .015), increased lymph node size (OR 28.16, p = .002), more extensive neck dissections (OR 8.70, p < .001), and human papillomavirus (HPV) negative cancer (OR 7.76, p = .010) as predictors of viable tumor. Decreased or unchanged but still enlarged lymph nodes after chemoradiation was a predictor of a negative neck dissection (OR: 0.11, p < .001). Conclusion Viable tumor in salvage neck dissections is associated with reduced survival. Increased lymph node size especially after radiotherapy alone for HPV negative cancers, is associated with viable tumor in salvage neck dissections. In case of decreased or unchanged lymph node size after chemoradiation, watchful waiting could be considered. PO-074 Concomitant chemoradiotherapy alone or with induction chemotherapy in advanced head and neck cancer. R. Teixeira 1 , A. Cavaleiro 1 , P. Vieira 2 , F. Aveiro 2 , G. Vieira 1 1 Quadrantes Funchal, Clinica de Radioncologia da Madeira, Funchal, Portugal 2 Hospital Central do Funchal, Hemato-Oncologia, Funchal, Portugal Purpose or Objective The purpose is to compare the treatment outcomes of patients with locally advanced head and neck cancer treated with Concomitant Chemoradiotherapy (CRT) alone versus induction chemotherapy (IC) followed by CRT in a retrospective study. squamous cell cancer. Material and Methods