7th ICHNO Abstract book

page 26 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

surgery and radiotherapy. There were 2 systemic relapses with perineural spread and bone metastasis- both patients died. 1 patient died at 1 year from unknown causes. Mean survival 51.625 months 5 Year survival 60%.Please see attached Kaplan-Meier graph. Conclusion Treatment of SNUC can be successful if when treated in a multi-modal way.

Maximum dose brain stem Maximum dose spinal cord

3270cGy 4191cGy p<0.01

3686cGy 4023cGy p=0.056

Mean dose midline mucosa (hyoid-cricoid) 4040cGy 5068cGy p<0.01 Mean dose midline mucosa (cricoid – sternum) 2658cGy 3324cGy p=0.07 Conclusion This is the only contemporary series of SCCUP head and neck where all patients have undergone a PET-CT as part of their diagnostic work up and the first series to compare outcomes from unilateral neck radiotherapy with VMAT to irradiating potential mucosal primary sites with VMAT. RT to INO does not result in more frequent emergence of mucosal primary or contralateral recurrence in SCCUP.The observed reduction in dose to OARs with INO approach may represent an opportunity to spare patients toxicity and would support further research to confirm the benefits of RT to INO. PO-050 Sinonasal undifferentiated carcinoma (SNUC) - endoscopic resection, chemo-radiation in 10 cases A. Dreyer 1 1 GVI Oncology Trust, Oncology, Cape Town, South Africa Purpose or Objective Sinonasal undifferentiated cancer is a rare and aggressive cancer starting at the Schneiderian mucosa with a high percentage of orbital or anterior cranial fossa invasion. Traditional treatment included extensive open surgery followed by radiotherapy +/- chemotherapy. Open surgery has a long recovery period, allowing regrowth of the cancer. We explore endoscopic surgery followed by chemo-radiotherapy as soon as possible. Material and Methods 10 consecutive cases presenting from 2006 to 2018 were audited. 2 Patients had transcranial surgery, 1 also had endoscopic resection, 8 patients had endoscopic resection. All were referred from one unit. All patients had weekly cisplatinum iv with radiotherapy, in 2 of these patients a weekly etoposide iv was added. Staging: 8 Patients was T4 N0 M0, 1 was T3 N0 M0, 1 was T2 N0 M0 but only had surgery as she was pregnant in the 2nd trimester -she recurred as T4 N0 M0 and received full treatment.Radiotherapy was IMRT or VMAT planning, Dose range was from 50 to 63 Gy with average dose 56.8Gy. The 50 Gy was for a patient that had previous radiation to the pituitary gland. With the last 6 cases retropharyngeal and level 2 neck nodes were prophylactically treated.

PO-051 Surgery versus Radiotherapy in T1N0 glottic cancer: 10 year outcomes N. Ferreira 1 , E. Netto 1,2 , L. Fonseca 1 , S. Esteves 3 , M. Labareda 1 , A. Mota 1 , R. Pocinho 1 , M. Magalhães 4 , F. Santos 1 1 Instituto Português de Oncologia de Lisboa Francisco Gentil- EPE, Radiation Oncology, Lisboa, Portugal; 2 NOVA Medical School, Faculdade de Ciências Médicas, Lisboa, Portugal; 3 Instituto Português de Oncologia de Lisboa Francisco Gentil- EPE, Clinical Research Unit, Lisboa, Portugal; 4 Instituto Português de Oncologia de Lisboa Francisco Gentil- EPE, Otorhinolaryngology, Lisboa, Portugal Purpose or Objective Early glottic cancer can be primarily managed by surgery (S) or radiotherapy (RT). The aim of this study was to compare the outcomes, patterns of failure and laryngeal preservation rates in patients with T1N0 glottic cancer treated at our institution. Material and Methods We performed a retrospective study of patients with T1N0 glottic cancer treated at our institution between January 2007 and December 2017, using a regional cancer database. The inclusion criteria were age ≥ 18 years, histologically proven squamous cell carcinoma, treated with upfront cordectomy/partial laryngectomy (S group) or RT (RT group). Patients with elective treatment of the neck (irradiated or dissected) were excluded. Local control (LC), disease-free survival (DFS), ultimate disease-free survival (UDFS), total laryngectomy-free survival (LFS) and overall survival (OS) were obtained using the Kaplan Meier method. Results 205 patients were identified, 198 (97%) males and 7 (3%) females with a median age of 64 years (41-85). Most were former or active smokers (87%) of a median of 45 pack- years (2-120), and had a good performance status (ECOG 0-1, 74%). CT1a was the predominant (84%) T stage. 174 patients were treated with upfront surgery, 17 of

Results

Endoscopic surgery but leaving the intracranial spread has led to a faster recovery and start of chemo-radiation. After chemo-radiation all patient went into complete remission. There was 1 nodal relapse was salvaged with