7th ICHNO Abstract book

page 38 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

Marginal recurrences highlight the need generous target volume delineation in the adjuvant setting. Selection of patients for whom contralateral neck radiotherapy can be safely omitted is challenging with a significant rate of contralateral regional failure.

Immunohistochemical markers showed promise as an adjunct for aiding the diagnosis. Conclusion Most of the OSCC in our study were associated with differentiated dysplasia, which frequently showed subtle histological changes. Through this study, we hope to alert pathologists and clinicians to the existence of differentiated oral dysplasia, a lesion which differs from the usual type of dysplasia histologically, and may possibly have different clinical features. Further research is warranted as to whether all differentiated oral dysplasia is high grade by definition, as is thought to be the case for differentiated dysplasia in other anatomical sites. Immunohistochemistry with CK13 and CK17 can be useful for supporting the diagnosis of differentiated oral dysplasia, especially for cases with subtle changes. Uniform terminology for precursor lesions leads to progress in knowledge and treatment. The WHO recently introduced ‘potentially malignant disorders’ in the oral cavity, and we hope in future will also recognize differentiated oral dysplasia. PO-073 Outcomes and patterns of failure of oral squamous cell carcinomas treated post-operatively with IMRT R. Waldram 1 , A. Taylor 1 , R. Prestwich 2 , S. Whittam 2 , L. Murray 2 , B. Al-Qaisieh 2 , K. Cardale 2 , S. Ramasamy 2 , P. Murray 2 , K. Dyker 2 , M. Sen 2 1 School of Medicine- University of Leeds, School of Medicine, Leeds, United Kingdom ; 2 Leeds Cancer Centre, Leeds Cancer Centre, Leeds, United Kingdom adjuvant (chemo)radiotherapy for squamous cell carcinoma of the oral cavity and to correlate locoregional recurrence patterns withradiotherapy target volumes. Material and Methods A single centre retrospective service evaluation of all patients receiving adjuvant (chemo)radiotherapy after surgery with curative intent for oral cavity squamous cell carcinoma between January 2013 and December 2016. Locoregional recurrences were mapped against planning target volumes using deformable image registration and visual assessment. Recurrences were categorised as in-field, marginal or out-of-field if >95%, 20-95%, and <20% of the recurrence volume was encompassed by 95% of the prescription isodose, respectively. Results 101 patients were included with a median follow up of 35.8 months. The most common subsite was the oral tongue (53%). Radiotherapy was delivered to: 52% primary site and bilateral neck, 47% primary site and ipsilateral neck. 25% of patients received concurrent radiotherapy. 2 year overall survival, disease free survival, local recurrence free, regional recurrence free and distant recurrence free survival were 68%, 72%, 87%, 85% and 87% respectively. A total of 21 patients experienced loco regional recurrence; 7 in-field, 6 marginal-field, 5 out-of- field and 3 mixed in field and out-of-field. Overall there were 6/47 (13%) contralateral neck recurrences in in patients who had received ipsilateral radiotherapy only; this included 3/26, 1/9 and 2/12 contralateral regional recurrences in patients with pN0, pN1 and pN2 disease who did not receive contralateral neck radiotherapy respectively. Conclusion Purpose or Objective To determine outcomes after

PO-074 Pharyngoesophageal laryngeal-hypopharyngeal

stricture

following treatment-

cancer

management outcome R. Sood 1 , P. Vinodbhai Rathod 1 , Y. Dokhe 1 , K. Kamaleshkumar Jani 1 , V. Sivakumar 1 , D.Balasubramanian 1 , S. Iyer 1 , K. Thankappan 1 , S. Sadasivan 2 1 Amrita Institute of Medical Sciences and Research Centre- Kochi- Kerala- India, Head and Neck Surgery, Kochi- Kerala, India; 2 Amrita Institute of Medical Sciences and Research Centre- Kochi- Kerala- India, Department of Gastroenterology, Kochi- Kerala, India Purpose or Objective Pharyngeal strictures are known to occur in patients receiving radiation therapy for carcinoma larynx and hypopharynx. Pharyngoesophageal stenosis results in severe dysphagia and dependence on alternate routes for enteral nutrition. This study reviewed treatment course and outcomes associated with stricture management. Material and Methods Retrospective study including patients of carcinoma larynx and hypopharynx attending tertiary centre from January 2016 to July 2018 was conducted. They were divided into groups based on intactness of larynx at the time of presentation with stricture (group I- chemoradiation used as primary modality, group II- upfront total laryngectomy followed by adjuvant chemoradiation and group III- salvage laryngectomy post chemoradiation). Details on sociodemographic, disease- subsite/ stage and treatment characteristics- type of surgery- primary closure/ pharyngeal reconstruction, radiation field, dose- fractionation, chemotherapy were analyzed. Stricture was diagnosed clinically and radiologically. Stricture site was subcategorized into zone I(cervical esophagus), Zone II(hypopharynx), Zone III(oropharynx) and Zone IV(thoracic esophagus). Length of segment and degree of obstruction was noted. Course of treatment and its outcomes reviewed. Results Total 145 cases were reviewed, 12 in group I, 32 in group II and 15 in group III. Hypopharynx was most common subsite in both subgroups (60% in group I and III, 65% in group II). All patients were managed with serial dilatations (average five times) with 4 in group I and 1 each in groupII and III had surgical management with augmentation of PE segment. Conclusion Cassification of patients based on disease, treatment and stricture characteristics helps in prognostication, guides treatment planning and helps in deciding surgical access when augmentation pharyngoplasty is necessary. PO-075 Disease-and treatment induced cachexia in locally advanced head and neck squamous cell carcinoma A.C.H. Willemsen 1,2,3 , A. Hoeben 2,3 , R.I. Lalisang 2,3 , A. Van Helvoort 1,4 , L.W.J. Baijens 2,5 , F.W.R. Wesseling 2,6 , F. Hoebers 6 , A.M.W.J. Schols 1 1 Maastricht University Medical Center+, NUTRIM School of Nutrition and Translational Research in Metabolism- Department of Respiratory Medicine, Maastricht, The Netherlands; 2 Maastricht University Medical Center+, GROW - School of Oncology and Developmental Biology,