7th ICHNO Abstract book

7th ICHNO 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ page 39

Maastricht, The Netherlands ; 3 Maastricht University Medical Center+, Division of Medical Oncology- Department of Internal Medicine, Maastricht, The Netherlands; 4 Nutricia Advanced Medical Nutrition, Danone Nutricia Research, Utrecht, The Netherlands; 5 Maastricht University Medical Center+, Department of Otorhinolaryngology- Head and Neck Surgery, Maastricht, The Netherlands; 6 MAASTRO Clinic, Department of Radiation Oncology, Maastricht,The Netherlands Purpose or Objective Chemo- or bioradiation treatment (CRT/BRT) of locally advanced head and neck squamous cell carcinoma (LAHNSCC) comes with high toxicity rates, often leading to temporary tube feeding (TF) dependency. Cachexia is a common problem in LAHNSCC. Yet, changes in body composition and muscle weakness during CRT/BRT are underexplored and strong evidence on the effect of TF on body composition during treatment is lacking. The aim of this cohort study was to assess (1) the relationship of fat-free mass index (FFMI) and hand grip strength (HGS) with CRT/BRT toxicity and outcome, (2) body composition in patients treated with chemoradiation (cisplatin) versus bioradiation (cetuximab), and (3) the effect of the current TF regime on body composition and muscle strength. Material and Methods LAHNSCC patients treated with CRT/BRT between January 2013 and December 2016 were included (n=137). Baseline measurements of body composition (bioelectrical impedance analysis) and HGS were performed. Toxicity grades (CTCAE) were scored. In a subset of 69 patients, weight loss, body composition, and HGS were additionally assessed during and after CRT/BRT. TF was initiated according to the Dutch guidelines for malnutrition. Results In this cohort, the incidence of baseline cachexia, defined as FFMI

PO-076 Predictors of postoperative pneumonia in patient undergoing oral cancer resection and its management R. Sood 1 , J. Paul 2 , S. Rajan 2 , S. Subramanian 3 , D. Balasubramanian 1 , S. Iyer 1 1 Amrita Institute of Medical Sciences and Research Centre- Kochi- Kerala- India, Department of Head and Neck Surgery and oncology, Kochi- Kerala, India ; 2 Amrita Institute of Medical Sciences and Research Centre- Kochi- Kerala-India, Department of Anaesthesiology, kochi- Kerala, India; 3 Amrita Institute of Medical Sciences and Research Centre-Kochi- Kerala- India, Department of Pulmonary Medicine, Kerala, India Purpose or Objective Head and neck resections carry a major risk of postoperative pulmonary complications. It adds to morbidity and mortality, adversely affects recovery and contributes to financial burden. Objective of this study is to find out incidence of pneumonia and establish its risk factors. Material and Methods It is a retrospective study including patients undergoing oral cavity resection at tertiary hospital from August 2017 to July 2018. 254 patients were analysed in terms of demographic profile, operative findings and postoperative course. Diagnosis of pneumonia was established by intensivist based on symptoms and signs. Results Incidence of pneumonia was 5.79% (15 out of 239). Average age of patients with pneumonia was 64.8 years, 60% were males. All had multiple comorbidities. Extensive resections of tongue, floor of mouth and alveolar arch with low preoperative serum albumin (<3.5g/dl) predispose to pneumonia (70%). Operative time of more than ten hours and delayed mobilization beyond four days were identified as risk factors. Most common isolate was Pseudomonas aeruginosa (60%) followed by Klebsiella pneumoniae. Twenty six percent were multidrug resistant strains. Average hospital stay was found to be prolonged by an average of 20 days. Conclusion The above mentioned risk factors predispose to development of postoperative pneumonia. Data from our cohort indicated a much lower incidence compared to published literature. We attribute this to our routine practice of ICU care in the immediate post operative setting with a nursing care ratio of 1:1, postoperative early mobilization, frequent tracheal toileting, chest physiotherapy, early diagnosis of pneumonia and prompt initiation of treatment. PO-077 Long-term outcome of IMRT with simultaneous integrated boost in nasopharyngeal carcinoma I. Linares 1 , M. Taberna 2 , J. Nogués 3 , R. Mesía 2 , D. Najjari 1 , J. Mases 1 , I. Guix 1 , M. Plana 2 , A. Lozano 1 1 Institut Català d'Oncologia, Radiation Oncology, Barcelona, Spain; 2 Institut Català d'Oncologia, Medical Oncology, Barcelona, Spain; 3 Hospital Universitario de Bellvitge, Otorhinolaryngology, Barcelona, Spain Purpose or Objective To report the long-term clinical outcomes of nasopharynx cancer patients treated with IMRT-simultaneous integrated boost (SIB) in a non-endemic area.