7th ICHNO Abstract book

page 74 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

concurrent chemoradiotherapy. Majority of the total radiation dose prescribed was 70 Gy. The results of this study showed that upon completion of radiochemotherapy (2 months post RT/CRT), patients who were treated with Biobran showed significantly higher mean hemoglobin ( p =0.010), hematocrit ( p =0.001), RBC ( p =0.001) and platelets ( p =0.017) and this was accompanied with significantly higher neutrophil count ( p =0.007) and lymphocyte count( p =0.045). Both groups had significant weight loss ( p <0.001). Lastly, patients treated with Biobran had better quality of life ( p =0.019) and lower treatment related toxicities compared to the placebo group. A subgroup analysis done showed that patients taking Biobran had lower rates of blood transfusion (p=0.00001) and hospital admission (p=0.000001), deaths (p=0.0003) and no incidence of tumor progression (p=0.25), infection (p=0.06) and metastases (p=0.029) as compared to placebo. Conclusion Results from this study showed better clinical outcomes based on hematologic parameters, nutritional status, treatment-related toxicities and quality of life in Biobran compared to placebo. These have led to fewer blood transfusions, less treatment delays and hospital admissions, avoidance of treatment mortalities and morbidities and improved quality of life. PO-142 Swallowing tests and aspiration pneumonia in advanced head and neck cancer : preliminary data G. Lazzari 1 , M. De Cillis 2 , A. Terlizzi 3 , G. Silvano 4 1 Azienda Ospedaliera SS. Annunziata Presidio Osped, Radiology, Taranto, Italy; 2 Azienda Ospedaliera SS. Annunziata Presidio Osped, Othorynolaryngoiatry Unit, Taranto, Italy; 3 Azienda Ospedaliera SS. Annunziata Presidio Osped Physics Department, Taranto, Italy; 4 Azienda Ospedaliera SS. Annunziata Presidio Osped, Radiation Oncology Unit, Taranto, Italy Purpose or Objective To assess whether swallowing (SWt) tests could be useful to predict aspiration pneumonia (AP) in locally advanced head and neck cancer by a retrospective study. Material and Methods Since 2011 swallowing tests have been applied in advanced head and neck cancer patients to supply properly nutritional devices according dysphagia severity. Data of 350 patients (pts) have been collected and analyzed. Aspiration pneumonia was defined as clinical symptomatic pneumonia combined with G3/G4 dysphagia radiation related and radiologically detected with no evidence of microrgasnisms responsible for atypical pneumonia. Dysphagia was defined by CTCAE v4.03 criteria. Swallowing tests were assessed at baseline and at 30 Gy and 50 Gy. The test consisted of 3 steps : solid food intake (1), semisolid food intake (2) and liquid intake of a metilene blue solution (3) phases. Variables as tumor site, radiation technique, smoking, chemotherapy, age, comorbidities were also accounted. Chi-squared and univariate Cox proportional hazards model were conducted to assess the relation between altered SWt and AP. Statistical significance was assumed at P < .005. Pearson’s covariance test was applied for multivariate analysis. Results Data of 350 patients treated since 2011 were analyzed. Grade G3 dysphagia aspiration pneumonia occurred in 50/350 pts (14%) and G4 in 30/350 (8.5%). Univariate analysys showed an SWt 2 at 30 Gy as a risk factor (p<.05)

Purpose or Objective This time-dependent study aimed to analyze the prevalence of mental disorders in tongue cancer survivors by using claims data in South Korea. Material and Methods We confirmed mental disorders in a nationwide cohort of 2,195 patients who were diagnosed with tongue cancer during the period between January 2010 and December 2014. We categorized the prevalence of mental disorders based on age and specific times before and after diagnosis. Results The median age at diagnosis of prostate cancer was 57 years. Within 1 year before the diagnosis of prostate cancer, a total of 187 patients were diagnosed with a mental disorder. Among the first diagnoses of each patient, the common mental disorders were anxiety (31.4%, n = 232) and depression (33.0%). Anxiety was frequent before trearment of tongue cancer, while depression was frequent after treatment. The overall frequency of mental disorders peaked within 2 months after the cancer treatment. Conclusion Mental disorders in tongue cancer survivors showed different patterns of prevalence between before and after cancer treatment, as well as between age groups. Timely diagnosis and intervention for psychological distress could promote quality of life for tongue cancer survivors PO-141 The Effects of Biobran on Head and Neck Cancer Patients Undergoing Radiotherapy: A Double Blind RCT J.A. Flores 1 , D.F. Tan 1 , M.A.G. Reyna 1 , M.J. Calaguas 1 , J. Canedo 1 , E.M. Chiong 1 , C. Yu 1 , L. Rodriguez 1 , R. Marquez 1 1 Jose R. Reyes Memorial Medical Center, Department of Radiotherapy, Manila, Philippines Purpose or Objective Radiation treatment delays in the management of head and neck malignancies secondary to anemia and poor nutritional status had greatly affected local control and survival. This study aims to determine the immunomodulating effects of Biobran as a supplement among head and neck cancer patients in addressing radiation treatment complications such as anemia, leukopenia, weight loss and improvement of quality of life. Material and Methods A total of 65 patients were enrolled in a double blind randomized study either to placebo or the Biobran Patients were given 3 grams of either placebo or Biobran per day, starting two weeks before the start of treatment, during radiation/chemoradiotherapy, and for two months after radiotherapy or radio-chemotherapy. Complete Blood Count (CBC), Body Mass Index (BMI), percent weight loss and EORTC Quality of Life questionnaires for Head and Neck Cancer Patients QLQ H&N35 were used to assess the degree of anemia, weight loss and evaluate quality of life. These parameters were obtained weekly starting 2 weeks prior to start of treatment, weekly during the course of radiotherapy/radio-chemotherapy and at 1 month and 2 months after treatment completion. Results 65 patients were enrolled in the study from November 2016 to February 2018. The median age were 52 years old, and majority were male. Most of the patients’ malignancies were nasopharyngeal type with squamous cell carcinoma histology that are undifferentiated. Most of the patients had locally advanced stage and were given