7th ICHNO Abstract book

page 76 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

scale). A clinical examination is performed jointly with radiation oncologist, otolaryngologist and speech pathologist, involving laryngeal evaluation with videostroboscope (VS) and laryngoscope. Statistical analysis will be performed to compare voice outcome and clinical evaluation of larynx in two treatment modalities (RT and LM). Results A total of 30 patients, average age of 74 years (range 54- 86), received RT with a total dose of 66-70 Gy, 2Gy/day, using 3-dimensional conformal technique. 15 patients received LM. Overall tumor stage distribution was: Tis (8.9 %), T1 (86.7%), and T2 (4.4%). All patients except one achieved a complete response after definitive RT. The median follow-up was 40.5 months (range 6-115 months). OS and PFS were 96.6% and 96.6% for RT group and 93.3% and 86.7% for LM group; 1 patient experienced disease failure 24 months after radical RT, while 2 patients failed after LM. No long-term RT toxicities greater than G2 occurred. From the original sample of 45 patients, in the context of ongoing VQ analyses 16 patients were evaluated to date. In tables we reported the summary of average VHI-30 and GRBAS scores, vocal acoustic analysis and VS evaluation in both groups.

Conclusion The preliminary results from the limited recorded data seem to show a more favorable voice outcome in RT patients. We attempt to complete this study and to perform a comparative statistical evaluation RT vs LM group, in order to confirm this result. PO-146 Radiation therapy of sinonasal carcinoma: A multidimensional study of sequelae and quality of life M.B. Sharma 1 , K. Jensen 2 , S.F. Urbak 3 , M. Funding 3 , S.S. Korreman 4 , C. Grau 4 1 Aarhus University Hospital, Department of Oncology, Aarhus C, Denmark; 2 Aarhus University Hospital, Danish Center for Particle Therapy, Aarhus, Denmark; 3 Aarhus University Hospital, Department of Ophthalmology, Aarhus, Denmark; 4 Aarhus University Hospital, Department of Oncology- Danish Center for Particle Therapy, Aarhus, Denmark