7th ICHNO Abstract book

page 82 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

resulting in a 3.2 times higher risk of early death in the palliative treatment group. Conclusion Identification of patients with an increased risk for early death reveals both patient- and disease-related factors and thus have the potential to affect their HNC management decision making. Older patients with an advanced stage disease, increasing WHO performance class, tumor location in the hypopharynx, and/or palliative treatment decision are more likely at risk of early death. PO-155 Epidemiological aspects of cancer of the nasal cavity and paranasal sinuses in the Republic Belarus Z. Kaliadzich 1 , M. Makarevich 2 , A. Evmenenko 3 1 N.N. Alexandrov National Cancer Center- Republic of Belarus, Laboratory of Head and Neck Oncology and Neurosurgery- Head- MD- PhD., Minsk, Belarus ; 2 N.N. Alexandrov National Cancer Center- Republic of Belarus, Head and Neck Oncology Department- MD, Minsk, Belarus; 3 N.N. Alexandrov National Cancer Center- Republic of Belarus, Anti-cancer Department, Minsk, Belarus Purpose or Objective Malignant tumors of the nasal cavity (NC) and the paranasal sinuses (PS) are the serious medical and social problem of nowaday clinical oncology. More than 70% of patients admitted for treatment in the later stages of the disease with locally common processes. Material and Methods Belarusian Cancer Registry Results According to the Belarusian Cancer Registry in the Republic of Belarus, over the period from 2008 to 2017, on average, more than 80 new cases were detected per year with a tendency for the annual growth of this indicator (from 83 to 87 cases). There was a tendency to an increase in incidence rates per 100,000 population from 0.8 - in 2008 to 0.9 - in 2017, respectively. The number of cancer patients followed up by the end of the year was 248 in 2008 and 336 in 2017, of them registered for 5 years or more, 87 were in 2008 and 146 in 2017. It is worth noting that from 2008 to 2017 the number of cases of detection of this pathology in the I-II stages decreased from 36.1 to 19.5%. Despite this, special treatment under the radical program was carried out in 58.7 and 50.0% of cases, respectively. The five-year adjusted cumulative survival rate (all stages in %) was 25.8% in 2008 and 34.0% in 2017. In view of the reduction in the number of newly detected cases in I-II stages, it is worth noting the necessity and importance of determining background, facultative and obligate precancerous conditions, early diagnosis in the framework of the implementation of screening programs for early detection of cancer. Optimization of approaches for combined and complex treatment of patients with cancer of NC and PS, as well as the introduction of principles and new approaches to their early diagnosis in practical healthcare, improved survival rates of patients with this severe pathology: thus, over the past 10 years, an increase in 5-year adjusted cumulative survival was observed patients with I and II stages from 53.6 to 59.8%, with III - from 28 to 45.6% and with IV - from 12.5 to 21.4%, respectively. One-year mortality decreased from 41.5 to 23.9%, respectively. There was a tendency to decrease in mortality rates per 100,000 population and cancer mortality-incidence ratio: from 0.6 to 0.5 and from 66.7 to 55.6%, respectively.

S. Wu 1 1 Taipei Medical University Hospital, No.111- Section Department of Radiation Oncology, Taipei, Chinese Taipei Purpose or Objective To propose a risk classification scheme for locoregionally advanced (stages III and IV) head and neck squamous cell carcinoma (LA-HNSCC) by using the Wu comorbidity score (WCS) to quantify the risk of curative surgeries. Material and Methods This study included 55 080 patients with LA-HNSCC receiving curative surgery between 2006 and 2015 who were identified from the Taiwan Cancer Registry database; the patients were classified into 2 groups, mortality (n = 1287, mortality rate = 2.34%) and survival (n = 53 793, survival rate = 97.66%), according to the event of mortality within 90 days of surgery. Significant risk factors for mortality were identified using a stepwise multivariate Cox proportional hazards model. Results The patients were divided into low- (WCS, 0-6; 90-day mortality rate, 0%-1.57%), intermediate- (7-11; 2.71%- 9.99%), high- (12-16; 17.30%-20.00%), and very-high- (17- 18 and >18; 46.15%-50.00%) risk strata. The 90-day survival rates were 98.97%, 95.85%, 81.20%, and 53.13% in the low, intermediate-, high-, and very-high-risk patients, respectively (log-rank P < .0001). Conclusion The WCS is an accurate tool for assessing curative-surgery- related 90-day mortality risk in patients with LA-HNSCC. PO-154 Early mortality after Head and Neck cancer diagnosis - Who and Why? C. Talani 1 , L. Farnebo 1 , A. Mäkitie 2 , G. Laurell 3 1 Linkoping University Hospital, Department of Otorhinolaryngology - Head and Neck surgery, Linkoping, Sweden ; 2 Helsinki University Hospital, Otorhinolaryngology - Head and Neck surgery, Helsinki, Finland; 3 Uppsala University, Department of clinical sciences- ENT, Uppsala, Sweden Purpose or Objective The aim of this study was to identify risk factors for early death despite intent of treatment, in order to better predict and monitor patients at risk. Material and Methods This is a nationwide, Swedish Head and Neck Cancer Registerbased series of 9733 HNC patients investigated for a possible risk profile for early death. Results A total number of 9733 patients were included in this study. Altogether 925 (9,5%) died within six months. Patient-related factors as well as tumor-related factors affected early death. The older the patient, the higher the risk for death within six months, and for every year the patients’ age increased the risk for early death increased with 2.3% (p<0.001). For every increase in WHO performance class, the patient had a 20% increased risk of death within 12 months. Primary tumor location in the hypopharynx correlated with the greatest risk for early death, with a 24% risk increase if the tumor location was hypopharyngeal instead of oral cavity (p<0.024). Patients with a Stage IV disease had 3.7 times increased risk for early death as compared with those with Stage I. Among the 8751 patients receiving curative treatment, 396 (4.5%) died within six months, whereas 478 (54,2%) of the 882 patients with palliative treatment died within six months,