7th ICHNO Abstract book

7th ICHNO 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ page 85

RPN) of 34 patients with epithelial non-glandular SNCs receiving IMRT with or without chemotherapy were retrospectively measured. We defined Total GTV (Total GTV) as sum of the three aforementioned GTVs, while GTV total-nodes (GTV-TN) included GTV-RPN and GTV-N. The GTV variables were analyzed in relation with OS and PFS. Survival curves were estimated using the Kaplan-Meier method and compared with the Log-rank test. We also estimated the crude cumulative incidence (CCI) of locoregional relapses only. The optimal volume cut-off value was determined using an outcome-oriented method among the observed values. Results 13 patients had positive neck nodes, 9 patients had positive RPNs, 16 patients had neck and/or RPN involvement. The 2- and 5-year OS, PFS, LR-CCI and DM- CCI are reported in Table 1. GTV-T was significantly associated with decreased OS (p=0.003) and PFS (p=0.003). Moreover, patients with Total-GTV smaller than 149.44 cm³ had better OS and PFS than patients with higher volumes (p<0.0001 for both) (Figure 1). Neck nodal metastasis impacted on OS and PFS (p=0.030 and p=0.033, respectively), but GTV-N did not (p=0.961; p=0.958). RPN metastasis was not associated with prognosis (OS: p=0.400; PFS: p=0.104). When GTV-RPN was added to GTV- N (GTV-TN), a relation with PFS (p=0.041) and a trend toward significance for OS (p=0.075) were found.

of data analysis. 9% (n=4) of patients relapsed in this time frame. 3 of these 4 patients received PORT, and only 1 relapsed within the radiotherapy field. These patients all went on to receive further treatment in the form of chemotherapy, whole brain radiotherapy, surgery or hormonal treatment. Conclusion Our data suggests that a core biopsy (rather than FNA) as the initial diagnostic procedure has greater correlation with the final operative histology and avoids a repeat biopsy procedure; this has to weighed up against the increased morbidity of the procedure. In 75% of cases radiotherapy was offered as per our local guidelines on the basis of 1 or more major criteria or 2 or more minor criteria being present. Whilst there are no published randomised controlled trials looking at the role or indications for PORT in the management of MSGT, this is in line with combined recommendations from other retrospective studies. Given the relative good prognosis of MSGT and the fact that relapse may occur later than 5 years, long term data analysis is required to define meaningful survival data or examine sites of relapse in relation to radiotherapy fields. Of note the majority of our caseload represents early stage disease (60% T1-2 and 70% N0) and therefore this is perhaps another explanation for the low relapse rate. PO-160 Tumor and retropharyngeal nodal GTVs prognostic role in unresectable non-glandular sinonasal cancers L. Ferella 1 , A. Cavallo 2 , R. Miceli 3 , N.A. Iacovelli 1 , T. Giandini 2 , E. Pignoli 2 , G. Calareso 4 , P. Bossi 5 , G.L. Gravina 6 , P. Nicolai 7 , P. Castelnuovo 8 , C. Piazza 9 , L. Licitra 10 , C. Fallai 1 , E. Orlandi 11 1 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Radiotherapy 2, Milano, Italy ; 2 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Medical Physics, Milano, Italy; 3 Fondazione IRCCS Istituto Nazionale dei Tumori, Clinical Epidemiology and Trials Organization Unit, Milano, Italy; 4 Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Radiology, Milano, Italy; 5 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Head and Neck Medical Oncology, Milano, Italy; 6 University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy; 7 University of Brescia, Department of Otorhinolaryngology-Head and Neck Surgery, Brescia, Italy; 8 University of Insubria and ASST Sette Laghi- Ospedale di Circolo, Department of Otorhinolaryngology, Varese, Italy; 9 Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Otolaryngology- Head and Neck Surgery, Milano, Italy; 10 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Head and Neck Medical Oncology- Department of Oncology and Hemato-oncology- University of Milan, Milano, Italy; 11 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Radiotherapy 2- Unit of Radiotherapy 1, Milano, Italy Purpose or Objective To evaluate the prognostic role of gross tumor volumes (GTVs of primary tumour and positive lymph nodes) on overall survival (OS) and progression-free survival (PFS) in locally advanced unresectable sinonasal cancer (SNCs) treated with definitive IMRT with or without chemotherapy. Material and Methods Primary tumour GTV (GTV-T), pathological neck nodes GTV (GTV-N), positive retropharyngeal nodes GTV (GTV-

Conclusion Our results show that tumor volume is a powerful predictor of outcome in SNCs. It could be useful to identify patients with worse prognosis deserving different treatment strategies PO-161 Mutational profile of epithelial, non-glandular sinonasal cancers into 2 prospective clinical trials L. De Cecco 1 , M.S. Serafini 1 , S. Canevari 1 , D. Penso 1 , P. Nicolai 2 , P. Castelnuovo 3 , M. Benazzo 4 , A. Sponghini 5 , E. Orlandi 6 , B. Vischioni 7 , C. Piazza 8 , C. Resteghini 9 , L. Licitra 9 , P. Bossi 9 1 Fondazione IRCCS Istituto Nazionale dei Tumori, Experimental Oncology and Molecular Medicine, Milan, Italy ; 2 Spedali Civili, Otolaryngology- Head and Neck Surgery, Brescia, Italy; 3 Ospedale di Circolo, Otolaryngology- Head and Neck Surgery, Varese, Italy; 4 Policlinico San Matteo, Otolaryngology- Head and Neck Surgery, Pavia, Italy; 5 Azienda Ospedaliera