7th ICHNO Abstract book

7th ICHNO 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ page 87

anti-Tg antibodies level as well as US was performed every 6 months for 5 years, then yearly. Restaging with Total body scan with radioiodine or 18FDG TC/PET was prescribed in case of raise of Tg level and/or positive US. Informed consent for use of anonymized data for scientific purpose was expressed. Results After primary treatment for DTC, 70 out of 1222 patients experienced a first locoregional nodal recurrence after a median time follow up of 21.6 months (range 3-334 months). Patients characteristics are shown in table 1. Treatment consisted of surgical (with or without adjuvant treatment) and non-surgical approach in 65 (93%) and 6 (7%) patients, respectively. Median follow up was 81.8 months (range 4.5-248.7 months) during which we observed a second relapse in 24 (34%) patients. Pattern of failure consisted in locoregional lymph nodes and distant sites in 19 (79%) and 5 (21%) patients, respectively. Five years-Relapse Free (RFS) and Overall Survival (OS) were 68.5% and 97.1%, respectively as shown in figure 1. At the last follow up 56 (80%), 7 (10%), 3 (4%) and 4 (6%) patients were alive with no evident disease, alive with disease, dead of disease and dead for other causes, respectively. Of the 6 patients treated with non-surgical approach (i.e. I-131 in 4 pts, external beam radiotherapy in 1 patient and TSH suppression in 1 case), only 1 patient had a second recurrence and is alive with disease at the last follow up. The remaining 5 patients are alive with no evident disease.

PO-163 Desmoid tumors of the Head and Neck A. Schrey 1 1 Turku University Hospital, Otorhinolaryngology- Head and Neck Surgery, Turku, Finland Purpose or Objective Desmoid tumours (DTs) of the head and neck have typically been classified as extra-abdominal, although the anatomic challenges of the head and neck warrant consideration of these DTs as a special entity. We present a review of DTs and describe our series of five patients with DTs of the head and neck treated within 2 decades in a single tertiary care hospital. Material and Methods Altogether, fiftythree patients with DTs treated surgically at a tertiary care center over a 20-year period were retrospectively reviewed. Outcomes of the treatment of DTs of the head and neck (n = 5) were thoroughly analyzed as a case series. Results In our series of 5 patients with head and neck DTs, no patient experienced a recurrence during a median follow- up of 47.5 months (range 13 to 150), although all had positive histologic margins. Conclusion DTs are rare, histologically benign, but locally aggressive tumours. In our series of 5 patients with head and neck DTs, no patient experienced a recurrence during a median follow-up of 47.5 months (range 13 to 150), although all had positive histologic margins. The functional integrity of vital structures over meticulous radicality of the tumor resection must be considered, especially in the head and neck. PO-164 Regional nodal failure after primary treatment for differentiated thyroid cancer. G. Fanetti 1 , E. Borsatti 2 , T. Baresic 2 , C. Bampo 2 , A. Esposito 3 , S. Mazzone 3 , C. Mazzon 4 , E. Minatel 1 , A. Revelant 1 , S. Pisu 1 , A. Nappo 1 , E. Casanova Fuga 5 , M. Burello 5 , V. Giacomarra 3 , G. Franchin 1 , C. Gobitti 1 1 IRCCS Centro di Riferimento Oncologico CRO National Cancer Institute, Division of Radiation Oncology, Aviano, Italy; 2 IRCCS Centro di Riferimento Oncologico CRO National Cancer Institute, Division of Nuclear Medicine, Aviano, Italy; 3 S. Maria degli Angeli Policlinic Hospital, Division of Otolaryngology, Pordenone, Italy; 4 S. Maria degli Angeli Policlinic Hospital, Unit of Endocrinology and Metabolic Diseases, Pordenone, Italy; 5 IRCCS Centro di Riferimento Oncologico CRO National Cancer Institute, Division of Medical Physics, Aviano, Italy Purpose or Objective To evaluate the management and outcome of patients experiencing regional nodal relapse after primary treatment for differentiated thyroid cancer (DTC). Material and Methods Data of all consecutive patients treated at our Institution for DTIC were prospectively collected. All patients (at the time of first diagnosis) underwent surgery for non- metastatic DTC and received adjuvant radioiodine (I-131), if indicated. Regular follow up was performed with Thyroglobulin (Tg) and anti-Tg antibodies level and neck ultrasound (US). In case of suspicious nodes cytological proof of relapse was required and restaging was performed. Treatment of nodal failure was decided on the basis of clinic-radiological features and patient preference. After that, follow up examination with Tg and

Conclusion Savage treatment of locoregional failure is effective in disease control for DTC with high percentage of RFS and OS. Surgical approach represents the treatment of choice. In patients ineligible for surgery, I-131 and external beam radiotherapy offered a valid option of cure. in recurrent/metastatic salivary gland cancer of upper aerodigestive tract L.D. Locati 1 , S. Cavalieri 1 , C. Bergamini 1 , C. Resteghini 1 , S. Alfieri 1 , G. Calareso 2 , P. Bossi 1 , P. Quattrone 3 , R. Granata 1 , D. Galbiati 1 , F. Platini 1 , E. Orlandi 4 , L. Mariani 5 , L. Licitra 6 1 Fondazione IRCCS Istituto Nazionale dei Tumori, Head and Neck Medical Oncology Unit, Milan, Italy; 2 Fondazione IRCCS Istituto Nazionale dei Tumori, Radiology Unit, Milan, Italy; 3 Fondazione IRCCS Istituto Nazionale dei Tumori, Pathology Unit, Milan, Italy ; 4 Fondazione IRCCS Istituto Nazionale dei Tumori, Radiotherapy Unit, Milan, Italy; 5 Fondazione IRCCS Istituto Nazionale dei Tumori, Biostatistics Unit, Milan, Italy ; 6 Fondazione IRCCS Istituto Nazionale dei Tumori - University of Milan, Head and Neck Medical Oncology Unit-Medical Oncology Department, Milan, Italy PO-165 Phase 2 study on axitinib