7th ICHNO Abstract book

page 92 7 th ICHNO Conference International Conference on innovative approaches in Head and Neck Oncology 14 – 16 March 2019 Barcelona, Spain __________________________________________________________________________________________ 7th ICHNO

S analysis low PS (p=0.005), T3-T4 (p=0.021), Stage III-IV (p=0.046) and AWD Low (<9.236) (p=0.018) were significantly associated with lower LRC; low PS ( p<0.001) and Group 2 (p=0.006) were also associated with lower OS. Considering pts treated with RT alone AWD Low (<9.236) was significantly associated with lower LRC (p=0.04) whereas among pts treated with concomitant CTRT AWD did not affected LRC (p=0.18). The multivariate analysis confirmed the independent significant value of PS for the prediction of both LRC and OS (p=0.035 and p<0.001, respectively). As regards compliance evaluation, 38 (25.3%) pts interrupted RT due to toxicity for a median time of 1 day (range: 1-9), 20 and 18 pts were in group 1 and group 2, respectively (p= 0.508).

and 3-year LC, OS and DPFS were 65%, 94%, 93%, respectively. We could identify a significant negative impact of macroscopic tumor disease diagnosed on the planning CT and MRI before RT on LC ( p=0.026 ). In contrast, perineural spread ( p=0.661 ), T stage ( p=0.552 ) and resection status in operated patients (p=0.069) had no significant impact on LC. No grade ≥3 acute and no grade >3 chronic toxicity occurred. In two cases, late grade 3 side effects could be identified in form of a wound healing disorder three months after RT and temporal lobe necrosis six months after RT (n=2, 8%). Conclusion Accelerated hypofractionated active raster-scanned carbon ion radiotherapy for relative radio resistant malignant lacrimal gland tumors results in moderate acute and late toxicity with adequate local control rates. Nevertheless, local control for ACC histology still remains challenging and risk factors for local recurrence still unclear. Further follow up is necessary to evaluate long- term clinical outcome. PO-173 Adenoid cystic carcinoma of the Head and Neck: demographics, prognostic features, and outcomes Abstract withdrawn PO-174 Impact of weekly radiation dose on loco- regional control in elderly HNSCC patients L. Belgioia 1 , A. Bacigalupo 2 , F. Missale 3 , S. Vecchio 4 , E. Tornari 1 , C. Giannotti 5 , R. Corvò 6 1 University of Genoa, Department of Health Science DISSAL, Genoa, Italy ; 2 Policlinico San Martino, Radiation Oncology, Genoa, Italy; 3 University of Genoa, Department of Otorinolaringology- Head and Neck Surgery, Genoa, Italy ; 4 Policlinico San Martino, Medical Oncology, Genoa, Italy; 5 University of Genoa, Department of Internal Medicine and Medical Specialties- DIMI - Section of Geriatrics, Genoa, Italy; 6 University of Genoa, Department of Health Science DISSAL- Radiation Oncology, Genoa, Italy Purpose or Objective To evaluate if, in elderly HNC patients, LRC is influenced by average weekly radiation dose (AWD). Material and Methods From 2009 to 2017 the medical records of 150 consecutive HNC elderly pts were reviewed. AWD was calculated by dividing the total dose in Gray by OTT in weeks. Pts were divided in 2 groups according to age: Group 1 (70-75 y) and Group 2 (>75 y). Primary endpoint was LRC; secondary endpoints were OS and compliance to planned treatment. Results The median age was 76 years (range: 70-92), the distribution of pts by age was 72 and 78 pts in Group 1 and in Group 2, respectively; overall median f up was 23 months (range 0-99). Table 1 shows pts characteristics. Pts in group 1 (70-75 years) underwent to RT concomitant to systemic therapy and were treated with a IMRT more frequently than those in group 2 (p= 0.000 and 0.002, respectively). Group 1 was associated to lower T stage (p=0.0192) and high PS (p=0.037). The AWD was assessed for all but 10 pts (excluded because they did not completed RT: 1 died after 21.2 Gy and the others presented important cognitive impairment). The mean AWD was 9.28±0.92. Optimal cut-off of AWD for LRC was 9.236 (p=0.018). Median OS was 73 months. In univariate Poster: Special requirements for elderly patients

Pt Characteristics

All pts

Group 1

Group 2

N(%) 0.0029

N(%)

N° pts

Oral

Cavity

23 47 62 0

5(7) 28(39) 26(36) 13(18)

18(23) 19(24) 36(46) 5(6)

Oropharynx Larinx Hypopharynx

Primary site

Tis-T2 T3-T4

58 92 62 88

23(29) 55(71) 0.0192 38(49) 40(51) 0.0684 14(18) 64 (82) 0.8368

35(49) 37(51)

cT Stage

N0 N+

24(33) 48(67)

cN Stage

0-II III-IV

28 122 37 113

14(19) 58 (81)

Stage

Adj Radical

19(24) 59(76) 1

18(25) 54(75)

RT

140 10

72(92) 6 (8) 0.7474

68(94) 4(6)

Treatment completed Yes No

3DCRT IMRT/VMAT

75 75

48(62) 3(38) 0.000

27(37) 45(63)

RT Technique

Standard Slight accelerated

103 47

54(69) 2(31) 0.928

49(68) 23(32)

RT Schedule

CT Ctx No

34 26 92

26(36) 17(23) 30(41)

8(10) 9(11) 6 (79)

0.928

Systemic Therapy

0 1 2 3

84 49 14 3

49(68) 18(25)

35(45) 31(40) 10(13) 2 (3)

0.0374

PS

4(6) 1(1)

Conclusion In elderly pts an AWD of >9.236 Gy was found to be beneficial for RT alone regimen but not CTRT. PO-175 Adjuvant therapy in patients older than 70ys with Head and Neck cancer (HNC): Turkish HNC Group study E. Metcalfe 1 , O. Yazici 2 , E. Korkmaz Kirakli 3 , A. Altinok 4 , S. Aytac Aslan 5 , R. Ibrahimov 1 , P. Altinok 6 1 Neolife Oncology Center, Radiation Oncology, Istanbul, Turkey; 2 Ankara Numune Training and Research Hospital, Medical Oncology, Ankara, Turkey ; 3 Suat Seren Training and Research Hospital, Radiation Oncology, Izmir, Turkey; 4 Acibadem Maslak Hospital, Radiation Oncology,