ESTRO 2020 Abstract book

S12 ESTRO 2020

Results 350 patients were included from 11 centers. In accordance with EANM 1.0 guidelines,the requested acquisition time of PET-CT scans should be 60 +10 minutes after injection, therefore our final cohort consisted of 119 subjects (oropharynx: 57.1%; HPV negative: 73.1%). At a median follow-up of 42 months (range 5 – 98), the median LRC was 35 months (95% CI: 32 – 43), with a 74.5% 3-year rate. The experimental Xxxxx score had the highest diagnostic accuracy (76.5%) with a PPV for primary tumor (Tref), nodal disease (Nref) and composite TNref of 42.9%, 100% and 50%, respectively (table 2). Good inter-observer agreement was measured with the Krippendorff’s alpha coefficientat 3 time points (data not shown). A Xxxxx score of 5-6 was associated with poor OS at multivariate analysis (HR 6.0; 95% CI: 1.88-19.18; p=0.002). In addition, nodal PD according to PERCIST criteria was associated with worse LRC (OR for LR failure, 5.65; 95% CI: 1.26-25.46, p=0.024) and OS (OR for death, 4.81; 1.07-21.53, p=0.04)

Proton therapy may spare normal tissue and thus reduce late morbidity. To generate proper selection strategies for proton therapy, investigation of late toxicity is crucial. This study aimed to estimate incidence and severity of late morbidity after intensity modulated radiation therapy (IMRT) for SNC. Material and Methods Patients from two Danish institutions who were alive and without recurrence after IMRT for SNC from 2008 through 2016 were eligible for the study (n=43). Late morbidity was evaluated with a battery of standardized neurocognitive tests, cerebral diffusion MRI, comprehensive objective ophthalmological examination, blood samples, and olfactory function testing. Patient reported outcome was collected using EORTC-QLQ-C30+BN20, SNOT-22 and HADS. Results Twenty-seven of 43 eligible patients were enrolled; median age was 67 years (range 47-83). See table 1.

Conclusion In the frame of a standardized methodology, the feasibility of Xxxxx score was preliminarly validated, yielding a high nodal PPV. Prospective investigations are warranted to further evaluate its reproducibility and diagnostic accuracy. The strictly blinded approach we followed may justify why our qualitative interpretations underperformed mainly in terms of PPV for Tref, where integrating more imaging modalities and clinical feedback is useful PH-0041 Substantial long-term morbidity after radiotherapy for sinonasal cancer. A cross sectional study M.B. Sharma 1 , K. Jensen 2 , J. Johansen 3 , A. Amidi 4 , M. Funding 5 , S.F. Urbak 5 , D. Bechtold 6 , C. Grau 7 1 Aarhus University Hospital, Department of Oncology, Aarhus, Denmark ; 2 Aarhus University Hospital, Danish Center for Particle Therapy, Aarhus, Denmark ; 3 Odense University Hospital, Department of Oncology, Odense, Denmark ; 4 Aarhus University, Unit for Psychooncology and Health Psychology- Institute of Psychology, Aarhus, Denmark ; 5 Aarhus University Hospital, Department of Ophthalmology, Aarhus, Denmark ; 6 Odense University Hospital, Department of Ophthalmology, Odense, Denmark ; 7 Aarhus University Hospital, Department of Oncology- Danish Center for Particle Therapy, Aarhus, Denmark Purpose or Objective Radiotherapy of sinonasal carcinoma (SNC) carries a substantial risk of normal tissue exposure and late morbidity (fig.1).

Cognitive function: Compared with normative data, patients scored lower on tests of processing speed, attention, working memory, memory and learning, and verbal fluency (p-values<0.05). Poorer working memory was statistically significant associated with higher mean doses to the right hippocampus, right frontal lobe, and both temporal lobes. Poorer performance on verbal fluency was statistically significant associated with higher mean doses to both frontal lobes. Ocular toxicity: Seven patients had radiation-induced ocular toxicity, one being enucleated due to toxicity. We found correlations between grade 2 and 3 radiation-induced visual acuity impairment (CTCAE 4.0) and maximum dose to the optic nerve