ESTRO 2020 Abstract book

S500 ESTRO 2020

Conclusion A large database allows the creation of an OS prediction model in oropharynx cancer treated with RT-Cet.To confirm the robustness of the model and make it suitable for a possible clinical application an external validation is needed. PO-0843 Assessment of weight loss and subjective dysphagia after radiotherapy for head and neck cancer M. Maddalo 1 , G. Costantino 2 , M. Buglione 2 , L. Spiazzi 3 , G. Volpi 2 , A. Premi 2 , A. Donofrio 2 , A. Guerini 2 , A. Alghisi 2 , S. Pedretti 1 , L. Costa 1 , D. Greco 1 , C. Cominardi 1 , L. Pegurri 1 , S.M. Magrini 2 1 Spedali Civili di Brescia, Department of Radiation Oncology, Brescia, Italy ; 2 Università degli Studi di Brescia - ASST Spedali Civili di Brescia, Department of Radiation Oncology, Brescia, Italy ; 3 Spedali Civili di Brescia, Department of Medical Physics, Brescia, Italy Purpose or Objective To analyze the clinical and therapeutic farctors associated with weight loss and “patient-reported dysphagia” (PRD) after radical or adjuvant radiotherapy/concurrent radiochemotherapy treatment for Head and Neck Cancer (HNC). Material and Methods 238 consecutive patients (pts) treated for HNC at a single Institution (from July 2015 to December 2017) were retrospectively analyzed. The sites considered in our series were oropharynx (63, 26.5%), hypopharynx (21, 8.8%), larynx (38, 16%), oral cavity (53, 22.3%), nasopharynx ( 29, 12.2%), nose and paranasal sinuses (17, 7.1%) and salivary glands (10, 4.2%); finally thyroid, skin and unknown primary tumors (7, 2.9%). The longitudinal assessment of PRD and weight loss (WL) was performed only for those pts (58) that completed the Vanderbilt Head and Neck Symptom Survey-Italian Version 2.0 (VHNSS-IT) at 3, 6, 12, 18 months after treatment. Maximum scores of the "swallow-solid" (SS), "swallow-liquid" (SL) and "nutrition" (N) subscales of the VHNSS-IT and WL were correlated with clinical and therapeutic variables and acute and late toxicities (CTCAE v4). Results Of the all 238 pts analyzed 58 completed the VHNSS-IT throughout the follow up. The average WL at the end of treatment (EOT) was -4,54% of basal weight (BW) (p= 0,000). Pts kept to lose weight up to 1 month after EOT (p= 0,001) and the basal weight was reached after 12 months (p= 0,808). Moreover WL was significantly greater in relation to concurrent chemotherapy (CCHT), radical radiotherapy, enteral/parenteral (NET/NPT). Accordingly high-grade acute (AD) and late (LD) dysphagia, acute (AX) and late (LX) xerostomia affected WL. SL max scores were significantly higher in elderly patients and, along with SL scores, in those who reported alcohol consumption. Both SS and N were significantly higher in relation to NPT/NET use, to AD, LD and to trismus. Moreover N value was significantly higher in relation to CCHT, mucositis, AX, LX and to chronic laryngeal edema. All the results described are shown in Fig.1.

Conclusion Weight changes and subjective dysphagia were significantly related with many clinical and therapeutic variables analyzed. Patients reported outcomes are inexpensive and easy to use in daily practice. They can help clinicians to identify pts who need early intervention. WL after EOT highlights the need of more intensive nutritional support in selected pts. PO-0844 Worst pattern of invasion and its association with histopathological features in oral cavity cancer S.S. Nanda 1 , A.K. Gandhi 1 , M. Rastogi 1 , A. Patni 1 , R. Khurana 1 , R. Hadi 1 , S. Sapru 1 , S. Rath 1 , H. .B. Singh 1 , S. Kumar 1 , N.P. Singh 1 , N. Husain 2 1 Ram Manohar Lohia Institute of Medical Sciences, Radiation Oncology, Lucknow U.P, India ; 2 Ram Manohar Lohia Institute of Medical Sciences, Pathology, Lucknow U.P, India Purpose or Objective Definitive treatment for oral cavity squamous cell carcinoma (OCSCC) is surgery followed by post-operative radiotherapy (PORT) with or without chemotherapy. Apart from the traditional risk factors for PORT [T3/T4, node positive, lympho-vascular space invasion (LVI) or perineural invasion (PNI), close margin, tumour thickness], recently other prognostic risk factors are also being identified like depth of invasion (DOI), tumour budding (TB) and worst pattern of invasion (WPOI). Often the high risk factors coexist together and analysis of association of these novel factors may help to predict biological behavior. We aim to report the incidence of these factors and its association with other risk factors in post-operative OCSCC patients treated at our institute. Material and Methods Post-operative patients of OCSCC undergoing curative oncological resection were analyzed. High risk WPOI (WPOI-5) was defined as tumour dispersion of ≥1mm between tumour satellites. For this analysis we used high risk WPOI as (WPOI 4/5). TB is defined as the presence of single cancer cell or cluster of <5 cancer cells at the invasive front. DOI and staging were used as per AJCC 8 th edition. Chi square test was used for correlation between prognostic factors and a 2 sided p value of < 0.05 was considered statistically significant.