APBI 2016
Dose to the heart
Darby et al., NEJM, 2013. Rates of major coronary events increased linearly with the mean dose to the heart by 7.4% per gray with no apparent threshold.
Lee at al. Am J Cardiol, 2013. Patients with left-sided breast cancer treated with radiotherapy have a higher risk of severe stenosis involving the mid and distal left anterior descending arteries and the distal diagonal branches.
LAD artery dose ≈ maximum dose to small volume
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