APBI 2016

Predictive biomarkers

HER2

ER/PGR

HR cut-off

HER2 cut-off

• 10% in France • 1-9%= 1.4% BC • 1% ASCO

• > 10%, ratio ≥2 • ASCO 2013 / GEFPICS 2014 • Increase of 2+ category

Positive predictive value

Negative predictive value

30-50%

(<5% chance to respond to anti-estrogens or trastuzumab) HIGH 95%