APBI 2016

Ki67/Mib1

- Expressed in G1 , S , G2 et M - Semi-quantitative IHC

- Prognostic factor Mib1 ⇔ size (+)

grade (+) mitosis(+) ER(-)

- Predictive in neoadjuvant - Luminal A vs B, help to CT decision in ER+ BC (20% cut- off) - …but lack of reproducibility, especially for intermediate values 10-30%