AROI-ESTRO GYN Teaching Course

Linking DVH-parameters to clinical outcome HR CTV/Tumour Analysis (n=141, FIGO: IB-IVA, median follow-up=51 months) D90 for the HR-CTV and probability of local control 1

Entire population (n=141)

0.9

0.8

0.7

D90 HR CTV 90 Gy EQD2 >86% probability for local contr

0.6

0.5

0.4

D90 HR CTV 70 Gy EQD2 65% probability for local control

0.3

0.2

Probability of local control

0.1

0 10 20 30 ≥ 90% local control HR CTV D90 ≥ 86 Gy

Tumours > 5cm (n=76)

0

EQD2(α/β10)

70 60 80

90 100

110 120 130 140

50 40

D90 (HR CTV)

Dimopoulos et al., R&O 2010

Dimopoulos et al. IJROBP 2008