AROI-ESTRO GYN Teaching Course

Demonstration of clinical evidence for dose effect for CTVHR

3-year local control rates D90 CTVHR dose ≥85 Gy in 7 weeks:

• >94% in limited size CTVHR (20 cm3 ) • >93% in intermediate size CTV HR (30 cm3 ) • >86% in large size CTVHR (70 cm3 )

Doses of 90–95 Gy add 1–4% to local control

An increase of OTT by one week is equivalent to de-escalating CTVHR dose by 5 Gy

An increased CTVHR volume by 10 cm3 requires an additional 5 Gy for equivalent local control.

THÈME DU DIAPORAMA Tanderup adiother Oncol 2016;120:441–46

GUSTAVE ROUSSY