ATP 2016

Regional radiotherapy instead of axillary surgery

AMAROS trial (EORTC): Radiotherapy or Surgery of the axilla Donkers et al. Lancet Oncol 2015

• 4,806 BC patients (cN0)  sentinel node procedure

• Tumorpositive sentinel node(s):

Axillary RT (n=681) vs. Axillary surgery (n=744)

Median follow-up 6.1 years:

Regional recurrence rate at 5 years: 0.54% ALND vs. 1.03% ART (NS) Toxicity i.e. arm oedema at 5 years: 23% ALND vs. 11% ART

 Clinical practice: Increased use of regional RT

Donker Lancet Oncol 2014