ATP Barcelona 2017

How to consider the volume effect in dose-response models?

2

(

) π

x

1

DD t

50 50 ⋅ − = D

−

t



2

NTCP

dx e

=

γ

2

• Probit : Lyman

50

2

π

∞−

a 1

  

j    =  = 1

a j Dv

EUD

j

1

NTCP

=

• Logistic (log dose ): Niemierko

4   

γ

  

50

D

1

+

D

50