ATP Barcelona 2017

Clinical evaluation: comparison of toxicity data from different protocols • Biologically Effective Dose  A parameter that is independent from the fractionation  It doesn’t express a real delivered dose

α α + + = / /

β + + = d α β α / 0 / 1

1 D BED

D D

d

β

1 2

2 1

2

1

d

β

d D BED

d dN

  

  

  

⋅ =   

1

1

+

=

+

1

1

3

1

1

/

/

α

β

α

β

α/β : alfa-beta ratio

N : fraction number d 1 : fraction number

for the given effect