ATP Barcelona 2017

Parameters for clinical outcome: Small bowel Small bowel toxicity in patients with GYN tumors undergone or not to abdominal surgery: 1) 95 patients with GYN malignancies 2) 34 patients after surgery, 61 patients without prior surgery 3) Use of LASSO for modeling logistic regression over Vdose parameters

1 4

−

   

   

γ

1

   + = V TV

  

1

NTCP

=

50

ˆ

X

1

β

−

e

+

TV 50

= tolerance volume corresponding to 50% incidence of complications

V

= volume of small bowel receiving a given dose level = normalized slope of the volume response curve

γ

TF Lee et al. The Different Dose-Volume Effects of Normal Tissue Complication Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in Gynecological Patients with or without Prior Abdominal Surgery. BioMed Research International Volume 2014, Article ID 143020.