Abstract Book

ESTRO 37

S390

PO-0756 Respiration control by hypnosis during radiotherapy of lung cancer ： A preclinical and clinical trial Y. Liu 1 , R. Li 1 , Y. Xie 1 1 Shenzhen Institutes of Advanced Technology- Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, shenzhen, China Purpose or Objective Respiratory motion influences the accuracy of radiation during therapy. In previous study, hypnosis was proposed as a comfortable, effective without side-effects and psychological method to control respiratory motion for lung cancer patients. This study aims to verify the feasibility of hypnosis on respiration control in clinical for chest and abdomen tumor patients during radiotherapy. Material and Methods An experiment was carried out in hospital with five patient volunteers of chest or abdomen cancer participating in two conditions of trial, preclinical condition (laboratory peace) and clinical condition (CT machine scanning). The preclinical trial was carried out three days before clinical trial. For every condition, respiratory motion of each volunteer was detected (by BioPac system) for two states, normal state (NS) and hypnotist-guided hypnosis state (HGS). Inter-state and inter-condition difference of respiratory motion were explored. Results The results demonstrated that all volunteers had decreased respiratory amplitude in HGS than NS in preclinical condition (mean amplitude of 11211/6664µV in NS/HGS), while there were only two in clinical condition (mean amplitude of 6278/5907µV in NS/HGS) (Figure 1a). Across all volunteers, it was observed with a mean amplitude deduction of 28.6% in preclinical trail, 5.7% in clinical trial (Figure 1b), indicating the effectiveness of hypnosis for respiratory motion control. Moreover, an overall reduction of coefficient variation in HGS were observed for both preclinical and clinical trial (Figure 1c) which implied that hypnosis is helpful in respiratory stability. End-tail of inspiration/expiration were more close to baseline in HGS than NS for both two conditions, and in clinic than pre-clinic for two states (Figure 1d), indicating less fluctuations in HGS, and in clinical trial. Additionally, in preclinical condition, the motion of duty cycle for phase gating window in HGS was lower than the motion at the corresponding duty cycle in NS (Figure 2a). While no significant difference of duty cycle was observed in clinical condition (Figure 2b).

Figure 1. Respiratory amplitude and end-tail of inspiraiton/expiraiton of five patient volunteers in normal state (NS) and hypnotist-guided hypnosis state (HGS) of two conditions.

Figure 2. The motion of duty cycle for phase gating window at both inspiraiton and expiration of patient volunteers breathing waves between normal state (NS) and hypnotist-guided hypnosis state (HGS) in pre- clinical and clinical condition. Conclusion The results of feasibility in clinical indicate that the respiratory motion could be controlled for patients by hypnosis. After preclinical trial, patient volunteers are more adjusted to hypnosis for respiration control, suggesting that sufficient pre-training accounts for stable and effective respiratory motion control in clinical radiotherapy. PO-0757 Non-small cell lung cancer decision support based on distributed learning over multi-center data M. Field 1 , L. Holloway 2 , S. Vinod 3 , M.S. Barakat 1 , V. Ahern 4 , M. Bailey 5 , M. Carolan 5 , G. Delaney 3 , A. Ghose 6 , E. Hau 4 , J. Lehmann 7 , T. Lustberg 8 , A.A. Miller 5 , J. Van Soest 8 , D. Stirling 6 , J. Sykes 4 , S. Walsh 8 , A. Dekker 8 , D.I. Thwaites 7 1 University of New South Wales, Faculty of Medicine, Sydney, Australia 2 Ingham Institute and Liverpool and Macarthur Cancer Therapy Centres, Medical Physics, Sydney, Australia 3 Ingham Institute and Liverpool and Macarthur Cancer Therapy Centres, Radiation Oncology, Sydney, Australia 4 Sydney West Radiation Oncology Network, Radiation Oncology, Sydney, Australia 5 Illawarra Cancer Care Centre, Medical Physics, Wollongong, Australia 6 University of Wollongong, Faculty of Engineering and Information Sciences, Wollongong, Australia 7 University of Sydney, Institute of Medical Physics,