Abstract Book

ESTRO 37

S618

departmental committees, writing or updating policies and procedures, teaching students , completing coursework related to healthcare or performing oncology- related community service activities. The assumption is that therapists who serve the department beyond patient care will gain a broader understanding of healthcare, become more well-rounded and find new motivation and engagement in their roles. This is a win-win for staff, the department and most importantly the patients. Results Specific milestones include: • Improved Staff Engagement o 25% of eligible radiation therapists apply to participate each year o Increased interest and engagement in participating in department activities (process improvement, committees, teaching, policy and procedure review, etc.) 3 Career Ladder participants served 6-month rotations as charge therapists, overseeing floor and machine operations and in the moment team needs Promotion of one Career Ladder participant to a managerial level position Estimated annual payout in old model was $100,000. Actual payout in 2015 was $65,250 (35% reduction of cost) and actual payout in 2016 was $35,750 (64% reduction of cost). Conclusion The Career Ladder program is administered by a multi- disciplinary group of leaders that review applications and determine which therapists meet Career Ladder achievement and bonus criteria. This ensures fairness in evaluating applications and increases awareness/appreciation in contributions from other teams across the department. To date, the program has had incredible success across all radiation oncology sites. PO-1098 Association of XRCC1 polymorphism with laryngeal SCC & with treatment response to chemoradiation V. Raturi 1 1 kokilaben dhirubhai ambani hospital, Radiation oncology, mumbai, India Purpose or Objective To study “Association of XRCC1 Arg914Trp polymorphism with locally advanced laryngeal SCC and with treatment response to chemo-radiation”. Material and Methods A hospital-based case control study was conducted. DNA Isolation and Genotype Analysis is done for cases and control to see for XRCC1 Arg914Trp polymorphism and the treatment response in cases . Odds ratio (OR) with 95% confidence intervals (CI) was computed to estimate the strength association. Results The prevalence of hetero & mutant phenotypes was higher in cases when compared with the controls, which results in statistically significant increase in risk of laryngeal cancer associated with hetero phenotype of XRCC-1 & the mutant phenotype. Increase in risk associated with XRCC-1 hetero and mutant phenotype was seen with smoking, tobacco chewing and alcohol consumption and it was statistically significant. XRCC-1 hetero genotype and mutant genotype frequencies were • o Improved Opportunities for Career Development o • o Cost Reduction

higher in cases when compared to the controls with a history of smoking, tobacco chewing and alcohol intake. In our study, patients carrying XRCC1 G/G (wt) genotype showed enhanced sensitivity to CRT. Conclusion Our data suggests that XRCC-1 hetero & mutant genotypes are strong pre-disposing factors in locally advanced laryngeal SCC. It has demonstrated the influence of gene environment interactions (smoking or tobacco chewing and alcohol intake) in modifying susceptibility to Laryngeal cancer. Poor treatment response of CRT in cases with mutant & hetero genotype of XRCC-1 has demonstrated the role of polymorphism in predicting an individual’s response to CRT, and thus, may help in selecting a suitable treatment regimen. PO-1099 Lean method, live update - real-time librarian support for evidence based radiotherapy protocols S. Goldsworthy 1 , C. Regan 2 , J. Pawley 2 , S. McGrail 1 , S. McCormack 3 , M. Varughese 4 1 Taunton & Somerset NHS Foundation Trust, Radiotherapy- The Beacon Centre, Taunton- Somerset, United Kingdom 2 Taunton & Somerset NHS Foundation Trust, Library, Taunton- Somerset, United Kingdom 3 Taunton & Somerset NHS Foundation Trust, Radiotherapy Physics- The Beacon Centre, Taunton- Somerset, United Kingdom 4 Taunton & Somerset NHS Foundation Trust, Oncology - The Beacon Centre, Taunton- Somerset, United Kingdom Purpose or Objective Multi-Disciplinary Teams (MDT) are professionally driven to adopt the latest practice to ensure the best possible outcome for patients. However, there can be delays in the latest evidence reaching practice for logistical reasons such as resources and time. The radiotherapy MDT in partnership with Clinical Librarians developed a lean process to undertake the real-time live update of radiotherapy clinical protocols to enable a streamlined approach to the latest evidence reaching practice. Material and Methods Poster: RTT track: Risk management/quality management