Abstract Book

S738

ESTRO 37

Conclusion Hormonal status, mastectomy, and standard radiotherapy treatment are not related to the resilience. The use of hypofractionated Schedule and the use of no concomitant treatment seems to favor capacity of adaptation and coping models for breast cáncer. The use of anxiolytics or antidepressants contrary to what would be expected, do not favor resilience in breast cáncer. EP-1351 Analyses of doses with deep inspiration breath-hold Vs free-breathing 3D-RT in breast cancer. S. Blanco Parajon 1 , V. Vera Barragán 1 , L. Gómez Heras 1 , D. Rodríguez Latorre 2 , C. Prada García 1 , M.J. Caminero Cuevas 1 , G. Juan Rijo 1 , M.P. Pérez Payo 1 1 Hospital Universitario Central de Asturias, Radiation Oncology, Oviedo, Spain 2 Hospital Universitario Central de Asturias, Radiological Physics, OVIEDO, Spain Purpose or Objective The aim of our study is to compare the dose administered to the heart subvolumes and ipsilateral lung, in breast cancer patients treated with 3D-RT in deep inspiration breath-hold technique (DIBH) Vs free-breathing (FB). Material and Methods 25 locoregional breast cancer patients have been evaluated, 10 right breasts and 15 left breasts. Two CT plans, DIBH-CT and FB-CT, are acquired for each patient. The OARs delineated are: ipsilateral lung (IL), whole heart (WH), pulmonary artery (PA), ascending aorta (AA), superior vena cava (SVC), right coronary artery (RCA), left anterior descending artery (LAD), left circumflex (LC), right atrium (RA), left atrium (LA), right ventricle (RV) and left ventricle (LV). The delivered dose is 50 Gy with opposite tangential fields. Respiratory motion is monitored with the Varian real-time position management respiratory gating system (RPM). We analyze the maximum dose (DM) and the mean dose (Dm) for each structure, V10 in the heart and V20 in the IL, stratifying the patients according to the side and with or without treatment of regional nodes (axilla level III and supraclavicular). The results are analyzed using a one- tailed paired t-test.

Conclusion Hypofractionated breast radiation is a well-tolerated treatment even in patients with large breasts. Patients with PTV volume> 1500 should be extremely careful in the submammary region. The size of the breast should not be an impediment to receive hypofractionated radiotherapy treatments. EP-1350 Capacity of resilience during radiotherapy treatment in breast cancer D.M. Muñoz Carmona 1 , R. De Haro Piedra 1 , J. Nieto- Guerrero 1 , J. Flores Rodríguez 1 , B. López Díez 2 , M. Ortíz Gordillo 1 1 University Hospital Virgen del Rocío, Radiation Oncology, Seville, Spain 2 Psicooncology Ministry of Defense Military Corps of Health, Psicooncology, Seville, Spain Purpose or Objective We intend to analyze whether women during radiotherapy treatment score high in resilience and whether or not they are strengthened from the breast cancer process. Material and Methods An observational, descriptive, prospective study to whom we conducted the Wagnild and Young Resilience Survey. Results We analyzed 140 patients. Mean 61y.(47-86). 81% received hypofractionated schedule (40.05Gy/2.67Gy/15sessions); 20% standard schedule (50Gy/2Gy/25sessions). Postmenopausal 64%; Premenopausal 36%. Bilateral tumor 3.6%; Right breast 46.4%, left breast 50%. Conservative surgery 61%; lumpectomy 21%; Mastectomy 18%. Stage 0: 2%; Stage I: 46,8%; Stage II: 34.4%; Stage III: 17%. The average resilience score was 141.91 (138-145). Analyzing aCronbach reliability of 0.927 (high reliability). Resilience is not affected by the hormonal state p=0.152; The mastectomized patients did not score worse than the rest of those receiving conservative surgery p=0.116; There were no significant differences in hypofractionated and standard treatment (p=0.244), but patients with a hypofractionated had an average resilience score higher than those receiving the standard treatment. Concomitant treatment with radiotherapy, there is also no significant relationship p=0.140, but those that do not carry any concomitant treatment score higher in resilience. Patients taking anxiolytics or antidepressant, score lower than those who do not take P<0.001 and P<0.05.

Results We observe a statistically significant reduction (p<0.05) with DIBH in right-sided breast cancer patients, only in Dm and V20 in the IL, and DM in the AA. In the left-sided breast cancer patients, DIBH is associated with a statistically significant reduction in all structures except Dm and V20 in the IL, DM in the LA and Dm in the SVC. In patients with treated regional nodes, a statistically significant reduction is only observed in Dm and V10 in the heart, V20 in the IL and Dm in the LV. Without treated regional nodes, DIBH is associated with a statistically significant reduction in all structures except DM in the RCA, AA, RA and LA, DM and Dm in the SCV.