Abstract Book

S894

ESTRO 37

Material and Methods Patients were prospectively enrolled in the single- institution randomized study. Dose regimen was single- fraction of 16-Gy versus 3-fraction of 24-Gy. The primary objective is the rate of 4-month grade 3 or higher adverse events definitely, probably or possibly related to treatment. Spinal Instability Neoplastic Scoring (SINS) system were incorporated into the protocol to predict the adverse event of each anticipant. Local control was determined by serial post-treatment image scans. Results Between 2015/11 and 2017/5, SSRS was performed in 23 sites on 20 patients (including 18 lung cancer patients, 1 breast cancer patient and 1 prostate cancer patient). The median age was 58 years (range 45 - 79). The median KPS was 80 (range 70-100). Of the 23 sites, 20 were single level targets. Thoracic spine (n = 15) and lumbar spine (n=7) were the most common sites. Single fraction radiosurgery was delivered in 11 patients while 3-fraction regimen was delivered in 9 patients. Median follow-up was 11.03 months (95% confidence interval: 8.26-13.81 months). At 4 months, no patient experienced any grade 3-5 toxicity. Pain flare was not reported in the irradiated sites. There was no evidence of vertebral body fracture related to the SSRS in any patient in the treated area. Conclusion Both single fraction and three fraction SSRS could provide durable and favorable pain and local control for patients who have previously unirradiated spinal metastasis with mild/tolerable toxicity profile. EP-1663 Quality of Life study in elderly breast cancer survivors. Differences among axillary surgery groups J.I. Arraras 1 , A. Manterola 2 , J.J. Illarramendi 3 , G. Asin 2 , E. Salgado 3 , B. Ibañez 4 , A. Galbete 4 , M.A. Dominguez 2 1 Complejo Hospitalario de Navarra, Radiotherapeutic Oncology, , Spain 2 Complejo Hospitalario de Navarra, Radiotherapeutic Oncology, Pamplona, Spain 3 Complejo Hospitalario de Navarra, Medical Oncology, Pamplona, Spain 4 Navarrabiomed- Departamento de Salud-UPNA – REDISSEC, Methodology Unit, Pamplona, Spain Purpose or Objective Quality of Life (QL) is considered a key aim in elderly patients. There is an interest in studying QL in elderly breast cancer survivors, and also the differences among axillary surgery groups after a long follow-up period, The aim is to assess the evolution of QL in elderly breast cancer survivors along three years of follow-up since the start of the treatment, and to compare the QL among different axillary surgery groups. Material and Methods 138 out 173 patients ≥ 65 years in early disease stages who started treatment, completed the EORTC QLQ-C30 and QLQ-BR23, and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) questionnaires 3 years after radiotherapy end. These patients also filled in these questionnaires before the start of irradiation. Linear mixed effect models were used to evaluate longitudinal changes in QL, and whether these changes differed among axillary surgery groups (axillary node dissection, sentinel node biopsy and no surgery). Differences among axillary surgery groups were also Electronic Poster: Clinical track: Elderly

studied three years after the end of the treatment (Anova, Kruskal-Wallis, Chi Square). Results QL scores three years after the end of the treatment were high (>70/100 points) in most QL areas, with moderate limitations (>30 points) in sexual functioning and enjoyment. Compared with the pre-treatment assessment, an improvement of QL scores along the follow-up was observed for four areas: pain, nausea and vomiting, financial impact and breast symptoms. There was no worsening in any QL area. There were no significant differences in the changes between the pre-treatment and the follow up assessments among the three axillary surgery groups, except for a worsening of 12/100 in diarrhoea in the axillary node dissection group and 6/100 points in systemic therapy in the no surgery group, that were not related to RT. The axillary node dissection group had less future perspective (15 points), more diarrhoea (10 points) and appetite loss (7 points) in the three years follow-up assessment than the other two axillary surgery groups, and more lymphoedema (9 points) and difficulties to raise the arm (13 points) than the no surgery group. Conclusion Results suggest good patients’ adaptation to their disease and treatments in the long follow-up period, and to the administration of RT in early stages breast cancer patients. There were few QL differences between the axillary surgery groups that favoured less aggressive modalities EP-1664 Systematic review on radiotherapy in elderly patients with gastrointestinal upper abdomen tumors S. Ciabatti 1 , A. Guido 1 , L. Giaccherini 1,2 , V. Panni 1 , V. Dionisi 1 , G. Siepe 1 , A. Arcelli 1,3 , M. Buwenge 1 , G. Macchia 4 , F. Deodato 4 , S. Cilla 5 , V. Picardi 4 , F. Cellini 6 , G.C. Mattiucci 6 , V. Valentini 6 , S. Cammelli 1 , F. Frezza 3 , A.G. Morganti 1 1 Department of Experimental- Diagnostic and Specialty Medicine - DIMES- University of Bologna- S.Orsola- Malpighi Hospital, Radiation Oncology Unit, Bologna, Italy 2 Department of Oncology and Advanced Technology- Arcispedale S. Maria Nuova-IRCCS, Radiation Oncology Unit, Reggio Emilia, Italy 3 Bellaria Hospital, Radiation Oncology Unit, Bologna, Italy 4 Fondazione di Ricerca e Cura “Giovanni Paolo II”, Radiotherapy Unit, Campobasso, Italy 5 Fondazione di Ricerca e Cura “Giovanni Paolo II”- Università Cattolica del S. Cuore-, Medical Physics Unit, Campobasso, Italy 6 Policlinico Universitario «A. Gemelli»- Università Cattolica del Sacro Cuore, Department of Radiotherapy, Rome, Italy Purpose or Objective To evaluate feasibility and outcome of radiotherapy (RT) in the complex setting of gastrointestinal (GI) tumors of the upper abdomen in elderly patients Material and Methods A systematic review of the literature about patients aged ≥ 65 years, who underwent RT for GI neoplasms of the upper abdomen was performed using the PRISMA methodology Results A total of 9 papers, amounting to 4255 patients, were included in the analysis. RT was prescribed as single