Advanced Physics for Brachytherapy 2018

Objectives & Objective Functions Inverse Optimisation and Planning

d i j is the dose at the j th -sampling point for the i th -objective function:

~

k ASDP

N

N

i j

2

i jkl lkK lk k

  = feasible k 1 (x)

=

d

d Sxb

,

=

l

1

feasible Catheters

Active SDPs

Dwell times t lk

?

Binary catheter Selection ?

• x²

= t lk to avoid negative (non-physical) dwell time values t lk

lk

• , can (should) be calculated in a pre-processing step and are then available in a sense of a Look-Up-Table for the optimisation process. Implementations in this way make optimiser independent of the dose calculation engine considered ( TG 43, MC, BS, CC, other Engines ) i jkl d ~