Advanced Physics for Brachytherapy 2018

Inverse Optimisation and Planning

Objectives & Objective Functions

Grid-based discretisation ➔ Set of Feasible Catheters/Needles

!

=

= 5.5x10 16 combinations

!.

− !

1 x PTV 3 x OARs NT

18x clinically

73x feasible

2.5 mm grid

Ԧ

~

k ASDP

N

N

+∞

i j

2

i jkl lkK lk k

  = feasible k 1 (x)

=

d

d Sxb

,

=

l

1

= න

´

− ´

−∞

feasible Catheters

Active SDPs

Dwell times t lk

?

Binary catheter Selection ?