Advanced Physics for Brachytherapy 2018

Inverse Planning – using HIPO



~

M

kASDP

N

N

i j

2

i jkl

d       ) , , ( w t r f





feasible

=

(x)

d Sxb

1 =  = m

fw f m m =

Minimise

lk K lk k ,

=

=

k

1

l

1

• A heuristic combining SA & scoring for the binary part b • A quasi-Newton for the continuous part t = x² (optimisation)

30s – 120s (parallelised, ...)

< 1.0s

MILP

HIPO

HIPO: < 240 s (not parallelised) MILP solver CPLEX: ≈ 48 hrs