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Individual variation in normal tissue sensitivity

• Radiogenomics of normal tissue toxicity

• Definite evidence of true association between common genetic variants and toxicity 1

• GWAS in prostate cancer 2 • Variation at 1 locus linked to toxicity • P = 4.6 × 10 −11

1. Barnett GC et al. Radiother Oncol 2014; 111(2): 178-185 2. Fachal L et al. Nature Genetics 2014 Aug; 46(8): 891-4