Advanced TP

Summary 1: What is the necessary SBRT dose to achieve local control? - BED >100 Gy (3x15Gy, 4x12Gy, 5x10Gy, 8x7.5Gy) - still dose effect beyond - larger tumors may benefit from higher doses for LC but have higher risk of distant spread - negative effect of long treatment duration (<>11d) however, high-dose-CFRT/AFRT outcome comparable

risk for toxicity in SBRT for central tumors: ► more fractionated regimes

Question 2: What are the normal tissue constraints?

22 · 22. Januar 2016