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Radiation induced secondary cancer after breast radiotherapy • Most second cancers after radiotherapy are attributed to other factors, e.g. lifestyle and genetics Berrington de Gonzales Lancet Oncol 2011 • Contralateral breast cancer: In patients < 40 years: if mean dose > 1 Gy (dose-dependent) Stovall IJROBP 2008

• Other second primary cancers, e.g. lung, esophagus