Advanced TP

Toxicity – hypofractionated and conventional scheme

• No significant difference in toxicity

lung, cardiac, rib fractures, shoulder movement

• 40 Gy-arm: Less common normal tissue effects (START B trial) breast oedema, breast shrinkage, telangiectasia

Haviland Lancet Oncol 2013, Haviland NEJM 2010, Whelan NEJM 2010, START B Lancet 2008, START A Lancet Oncol 2008, Owen Lancet Oncol 2006