Advanced TP

Radiobiology for OAR - NTCP

• There are mechanistic derived models for predicting TCP (based on probability of tumor stem cells lost during the treatment) • There are not convincing mechanistic models for describing all side effect onset  Stem cells loss (dry mouth, myelopathy)  Abnormal cell growth (fibrosis, telangiectasia) • Likelihood of side effects onset is proportional to the administered dose  Using the probability density function of normal distribution (probit)  Using the probability density function of other statistical distribution (logit – Log dose )