Advanced TP

How to consider the volume effect in dose-response models?

2

(

) π

x

1

DD t

−

−

t

∫

2

NTCP

dx e

=

=

50 ⋅

γ

2

• Probit : Lyman

50

D

2

π

∞−

50

a 1

j    = ∑ = 1

  

a j Dv

EUD

j

1

NTCP

=

• Logistic (log dose ): Niemierko

4   

γ

  

50

D

1

+

D

50