Advanced TP

Reliability of radiobiological evaluation • Solution 1: different populations, different parameters to be used in dose-response model (Lyman)

1.0

Sequential CRT

Concomitant CRT

TD 50

46 (42 – 50) 2.7 (1.25 – 5) 3.4 (2.4 – 5)

TD 50

36 (34 – 56)

0.5

γ 50

γ 50

0.95 (0.71 – 1.11) 11.1 (1.3 – 14.3)

a

a

NTCP [*100 %]

0

0

40

80

120

Dose [Gy]

J Zhu et al. Analysis of acute radiation-induced esophagitis in non-small-cell lung cancer patients using the Lyman NTCP model. Radiother Oncol 97 (2010) 449–454.