Advanced TP

Parameters for clinical outcome: Small bowel

Baglan-Robertson threshold model for risk of acute small bowel toxicity

500

450

400

100 Absolute Volume of individual bowel loops [cc] 150 200 250 300 350

High risk (≈40%) of G3 or worse acute toxicity

CTCAE G3 : Abdominal pain, fever, change in bowel habits with ileus; peritoneal signs

Low risk (≈10%)of G3 or worse acute toxicity

50

0

0

5

10

15

20

25

30

35

40

45

Dose (Gy)

Kavanagh BD et al. Radiation Dose-Volume effects in the stomach and small bowel. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S101–S107, 2010.