Advanced TP

Parameters for clinical outcome: Urinary bladder

Dose (Gy), or dose/volume parameters

Irradiation type (partial organ unless otherwise stated)

Volume segmented

Notes on dose/volume parameters

Endpoint

Rate (%)

Bladder cancer treatment. Variations in bladder size/shape/ location during RT hamper ability to generate accurate data Prostate cancer treatment Based on current RTOG 0415 recommendation

Dmax <65

<6

Whole organ

3D-CRT

Grade > 3 late RTOG

V65 <50 % V70 <35 % V75 <25 % V80 <15 %

?

Whole organ

3D-CRT

Grade >3 late RTOG

• In the absence of any reliable data, clinicians might consider the dose limits listed in the conventional fractionation arm of the Radiation Therapy Oncology Group (RTOG) 0415 study

Viswanathan AN et al. Radiation Dose-Volume effects of the urinary bladder. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S116–S122, 2010.