Advanced TP

Cost Function

Minimize the energy imparted, subject to:

prescribed dose

dose in pixel i

maximum dose in OAR m

importance

minimize and

> D D

i

m OAR

(

)

∑

2

D D

−

OAR

i

m

∑

pixels OAR

w

+

m

OAR

OAR in Pixels

m

OARs all

m