Advanced TP

IMRT Treatment Planning

Medical Imaging (CT, MR, PET)

Clinical Objectives Targets, OARs, Dose-volume implicit objectives

PATIENT MODEL delineated organs, targets organ movement geometric uncertainties - PTV

Evaluate Treatment Plan

Objective Function

Dose Computation

Optimization Engine (select parameters that minimize the enumerated objective function)

Sharpe | ESTRO | June 2012 Adjustable Parameters MLC shape, number of apertures, number of MU ’ s, dose rate MACHINE MODEL Physical Geometry constraints & limits Beam number, angles, energy, MLC geometry, leaf speed

Treatment Delivery (computer control) (MLC)