Advanced TP

Exploring Trade-Offs in IMRT  Often difficult to balance coverage & sparing.  Multi-objective Pareto optimization formalizes the process – Multi-Criteria optimization.  Plan is “ Pareto optimal ” when no other plan is strictly better in at least one objective function while being no worse in every other objective.  Method:

 Pre compute a database of Pareto optimal plans, meeting a constraint (e.g. Dmin in PTV)  Planner or MD can interactively navigate through these plans, manipulating weights to understand in real time the tradeoffs involved in the particular case  With this new capability, one can generate “ tradeoff curves ” , or “ Pareto fronts ” .

Craft et al, Phys. Med. Biol. 50 5857–5868 (2005)